Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl

Oncotarget
Xinmiao YuFeng Jin

Abstract

TMEM88, a newly discovered protein localized on the cell membrane, inhibits canonical Wnt signaling. Immunohistochemic alanalysis of 139 breast cancers pecimens(64 triple-negative cancers and 75 non-triple-negative cancers) indicated that TMEM88 is expressed at significantly higher levels in breast cancer tissues (71.22%, 99/139) than in normal breast tissues (11.4%, 4/35; p < 0.001). The cytosolic and nuclear expression rates of TMEM88 were 57.81% and 9.37% in triple-negative and 52% and 33.33% (p = 0.5 and p = 0.001) in the non-triple-negative breast cancer tissues, respectively. Western blot analyses indicated that TMEM88 promoted Snail expression and inhibited Zo-1 and Occludin expression by interacting with dishevelled (Dvl) proteins, thereby stimulating invasion and metastasis in breast cancer. While cytosolic TMEM88 did not affect canonical Wnt signaling, cytosolic localization of this protein was positively correlated with both advanced TNM stage (p = 0.038 and p < 0.001) and lymph node metastasis (p = 0.01 and p = 0.002) in all and triple-negative specimens, respectively, and stimulated cell invasion by interacting with Dvls. Meanwhile, nuclear localization of TMEM88 was negatively correlated with lymph node metastasis...Continue Reading

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Citations

Dec 12, 2018·Molecular Carcinogenesis·Wen-Bin LiuJin-Yi Liu
Jul 19, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin ZhangJia-Qiang Liu
May 18, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rong LiuGuoxin Mao
Jun 11, 2019·CNS Neuroscience & Therapeutics·Kuan-Yu WangTao Jiang
Dec 24, 2018·Frontiers in Pharmacology·Kathleen Schmit, Carine Michiels
Dec 1, 2020·Technology in Cancer Research & Treatment·Lin GanGang Lyu

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Datasets Mentioned

BETA
MDA-MB-468

Methods Mentioned

BETA
immunoprecipitation
pull-down
Co-immunoprecipitation
transfection
PCR
surgical resection
electrophoresis
confocal microscopy
Assay

Software Mentioned

SPSS

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