CytoSorb, a novel therapeutic approach for patients with septic shock: a case report

The International Journal of Artificial Organs
Burkhard HinzRolf Kaiser

Abstract

Hemoadsorption using CytoSorb has gained attention as a potential immunotherapy to control systemic inflammation and sepsis. We report on a patient with septic shock, successfully treated with CytoSorb therapy. A 72-year-old male with periodically recurring infectious episodes was admitted with the suspicion of urosepsis. In the following hours his hemodynamic situation deteriorated markedly, exhibiting respiratory-metabolic acidosis, elevated inflammatory marker plasma levels, a severely disturbed coagulation, increased retention parameters, liver dysfunction, and confirmation of bacteria and leucocytes in urine. After admission to the ICU in a state of septic shock the patient received renal support with additional hemoadsorption using CytoSorb. Three CytoSorb sessions were run during the following days. The first and consecutive second session resulted in a reduction of procalcitonin, C-reactive protein and bilirubin and a markedly reduced need for vasopressors while hemodynamics improved significantly (i.e., cardiac index, extravascular lung water). Due to a recurring inflammatory "second hit" episode, another session with CytoSorb was run, resulting in a marked decrease in leukocytosis and liver (dys)function parameters. T...Continue Reading

References

Apr 25, 2008·Critical Care Medicine·Zhi-Yong PengJohn A Kellum
Mar 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Thomas Rimmelé, John A Kellum
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Dec 30, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Reshma BasuAnil Barwal

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Citations

Jan 15, 2019·The International Journal of Artificial Organs·Dana TomescuSimona Dima
Feb 15, 2019·Minerva anestesiologica·Katia Donadello, Enrico Polati
Jun 27, 2019·The International Journal of Artificial Organs·Silvius FrimmelSebastian Koball
Mar 30, 2017·Blood Purification·Andreas Faltlhauser, Frank Kullmann
Jul 19, 2018·Case Reports in Critical Care·Francesca LeonardisGaetano La Manna
Jan 28, 2017·Case Reports in Critical Care·Catalin Gabriel CirstoveanuSamantha Mc Kenzie Stancu
Jun 3, 2017·The International Journal of Artificial Organs·Stefanie MarekAndreas Kliegel
Oct 12, 2019·Scientific Reports·Maximilian DenzingerE Marion Schneider
May 20, 2017·The International Journal of Artificial Organs·Khosrow S HouschyarFrank Siemers
Jun 8, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sigrun FrieseckeAxel Nierhaus
Jul 6, 2019·Frontiers in Cardiovascular Medicine·Achim LotherDaniel Duerschmied
Nov 26, 2020·Advanced Healthcare Materials·Lana PapafilippouMarilena Hadjidemetriou
Nov 13, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marina RiederAlexander Supady
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marina RiederAlexander Supady
Jun 18, 2021·The International Journal of Artificial Organs·Maria GetsinaNatalia Beloborodova
Oct 5, 2021·Artificial Organs·Tom LiuMark Joseph

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