PMID: 9647052Jul 1, 1998Paper

Cytostatic lung perfusion by use of an endovascular blood flow occlusion technique

The Annals of Thoracic Surgery
M FurrerH B Ris

Abstract

Different modalities of cytostatic lung perfusion were compared regarding plasma and tissue drug concentrations to assess the efficacy of an endovascular blood flow occlusion technique. A cytostatic lung perfusion study with doxorubicin hydrochloride was performed on large white pigs (n = 12). Plasma and tissue concentrations of doxorubicin were compared for isolated lung perfusion with open cannulation (ILP), blood flow occlusion perfusion with open cannulation of the pulmonary artery alone (BFO), and intravenous drug administration (i.v.). In a fourth group, thoracotomy-free BFO perfusion was performed by endovascular balloon catheterization of the pulmonary artery (endovascular BFO). The 3 animals in this group were used to compare the doxorubicin-perfused pulmonary tissue with the contralateral nonperfused lobes after 1 month. The mean lung tissue doxorubicin concentration at the end of perfusion was 19.8 +/- 1.6 microg/g after ILP, 27.6 +/- 2.2 microg/g after BFO (p = not significant), and 3.0 +/- 0.8 microg/g after i.v. perfusion (p < 0.01). Whereas doxorubicin was not detectable in the plasma in the ILP group, concentrations ranged from not detectable to 0.44 microg/mL in the BFO group and from 0.31 to 0.84 microg/mL in ...Continue Reading

References

Feb 11, 1991·The Journal of Surgical Research·F A BaciewiczP K Chaudhuri
Mar 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A PotterS A Rosenberg
Aug 1, 1983·Cancer·M R JohnstonM R Boyd
Jul 1, 1980·American Journal of Surgery·J F HuthD L Morton
Jan 1, 1981·Journal of Surgical Oncology·C P KarakousisP Kanter
Jun 1, 1994·The Annals of Thoracic Surgery·H W PogrebniakH I Pass
May 22, 1998·The Annals of Thoracic Surgery·M FurrerH B Ris
Nov 1, 1961·The American Journal of the Medical Sciences·J F MORRIS, L M GOLDBERG

❮ Previous
Next ❯

Citations

Aug 24, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·H OmiyaH Imamura
Jun 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Paul E Van SchilGodehard Friedel
Jun 30, 2006·Thoracic Surgery Clinics·Jeroen M H HendriksPaul E Y Van Schil
May 2, 2003·Acta Clinica Belgica·P E Van Schil
Apr 6, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Müller, S Guadagni
Nov 28, 2015·Thoracic Surgery Clinics·Alison WardHarvey Pass
Oct 8, 2003·The Annals of Thoracic Surgery·Bart P Van PuttePaul E Y Van Schil
Mar 9, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Müller
Nov 28, 2006·The Annals of Thoracic Surgery·Thorsten KruegerHans-Beat Ris
Jun 30, 2006·Thoracic Surgery Clinics·Katherine S VirgoFrank E Johnson
Mar 22, 2006·Journal of Surgical Oncology·A van der ElstJ R M van der Sijp
Jan 12, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bart P van PutteGert Folkerts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.