Cytotoxic 20,24-epoxywithanolides from Physalis angulata

Steroids
Emma MaldonadoMahinda Martínez

Abstract

A new withanolide, physangulide B (1), was isolated from calyxes of Physalis angulata. This compound was also present in the aerial parts along with the known physangulide (4), which was isolated as the acetonide 3, and 24,25-epoxywithanolide D (6). Structures of these compounds were determined by analysis of their spectroscopic data, which indicated the presence of a 20,24-epoxy group in both physangulides. The structures of compounds 1 and 6 were confirmed by X-ray analysis of their corresponding acetyl derivatives 2 and 7. The structure of physangulide was originally described as the 22S withanolide 5, now its structure and configuration are revised to 4. Evaluation of the cytotoxic activity of compounds 1-3 against two human cancer cell lines indicated a potent activity of compound 1 and its derivative 2.

References

Jun 5, 1991·Journal of the National Cancer Institute·A MonksA Vaigro-Wolff
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Feb 6, 2004·Biological & Pharmaceutical Bulletin·Shinya NagafujiFumiko Abe
Aug 2, 2006·Chemical & Pharmaceutical Bulletin·Fumiko AbeJunei Kinjo
Jun 23, 2007·Journal of Natural Products·Yuanhu PanXianming Hu
Oct 1, 2011·Journal of Natural Products·Matheus S SáMilena B P Soares

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Citations

Jan 9, 2019·Natural Product Research·Jutatip BoonsombatSanit Thongnest
Dec 12, 2019·The Journal of Pharmacy and Pharmacology·Min HuangTao Shen
Apr 29, 2021·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Emma MaldonadoMahinda Martínez
Aug 21, 2019·Journal of Natural Products·Fernando R TorresEmma Maldonado
Aug 24, 2021·Acta Crystallographica. Section E, Crystallographic Communications·R Ya OkmanovB Tashkhodjaev
Nov 25, 2021·Natural Product Reports·Gui-Yang XiaFeng Qiu

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