PMID: 11933149Apr 5, 2002Paper

Cytotoxic activity of amooranin and its derivatives

Phytotherapy Research : PTR
T RabiV N Bhattathiri

Abstract

Amooranin, 25-hydroxy-3-oxoolean-12-en-28-oic acid, is a triterpene acid isolated from Amoora rohituka stem bark. The cytotoxic effects of amooranin and its derivatives were studied. Amooranin and its methyl ester showed greater cytotoxicity against MCF-7 and HeLa cells derived from tumour tissues with a 50% inhibitory concentration (IC(50)) of 1.8-3.4 microg/mL, compared with Chang liver cells from normal tissue with an IC(50) of 6.2-6.4 microg/mL, but amooranin exhibited no activity on HEp-2 and L-929 cells. However, its monoacetate derivative showed no inhibitory activity at 1-10 microg/mL dose levels. Of the cytotoxic isolates, the methyl ester derivative was inactive in in vivo evaluations in the Ehrlich ascites tumour cells at 50 and 100 mg/kg/day, demonstrating T/C values of 106% and 114%, respectively.

References

Sep 1, 1972·Cancer·E J Van Slyck, B M Schuman

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Citations

Oct 10, 2006·Breast Cancer Research and Treatment·Thangaiyan RabiSipra Banerjee
Jul 19, 2008·Breast Cancer Research and Treatment·Thangaiyan Rabi, Anupam Bishayee
Oct 9, 2013·Journal of Medicinal Chemistry·Lucienne Juillerat-Jeanneret
Sep 25, 2003·Breast Cancer Research and Treatment·Thangaiyan RabiEnrique Escalon
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Leo L ChanKenneth L Watkin
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Anupam BishayeeMarjorie Perloff
Nov 15, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Nisha R ParikhAnupam Bishayee
Nov 13, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Thangaiyan Rabi, Mathuram Venkatanarashiman
Feb 14, 2013·International Journal of Cancer. Journal International Du Cancer·Anupam BishayeeDeepak Bhatia

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