Cytotoxic activity of C-geranyl compounds from Paulownia tomentosa fruits

Planta medica
Karel SmejkalJosef Cvacka

Abstract

The newly discovered 5,7-dihydroxy-6-geranylchromone ( 1) was isolated from PAULOWNIA TOMENTOSA fruit and subsequently characterized. The structure of the isolated compound was elucidated on the basis of extensive NMR experiments including HMQC, HMBC, COSY, and NOESY, as well as HR-MS, IR, and UV. The cytotoxicity of 1 was evaluated using a plant cell model represented by tobacco BY-2 cells. The other phytoconstituents ( 2 - 8) previously isolated from P. TOMENTOSA were similarly evaluated together with the known flavanones 10 and 11. The cytotoxicity (human erythro-leukaemia cell line K562) and activity on erythroid differentiation of compounds 2 - 9 and 12 and 13 have also been evaluated. Acteoside ( 2) was determined to be the most toxic of the compounds tested on BY-2 cells, diplacone ( 6) on the K562 cell line. Some aspects of the relationship between the flavanone skeleton substitution and the metabolic activation necessary for a toxic effect are discussed.

Citations

May 3, 2011·Journal of Asian Natural Products Research·Jiang HeZhen-Dan He
Apr 5, 2011·Phytochemistry·Sergio RosselliKuo-Hsiung Lee
Sep 22, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Yeong Hun SongKi Hun Park
Nov 7, 2018·Anti-cancer Agents in Medicinal Chemistry·Rohit DuttAnil K Madan
Dec 24, 2010·British Journal of Pharmacology·Peter KollárAleš Hampl
Jan 1, 2015·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kristýna Schneiderová, Karel Šmejkal
Jan 1, 2019·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Chun-Lei ChengWen-Zhao Tang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakub TremlKarel Šmejkal
Mar 3, 2010·Journal of Natural Products·Karel SmejkalKarel Dolezal
Oct 3, 2017·Journal of Natural Products·Hyung Won RyuSei-Ryang Oh

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