Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia.

BMC Complementary and Alternative Medicine
Nurul A M N HazalinAbu Bakar Abdul Majeed

Abstract

Endophytes, microorganisms which reside in plant tissues, have potential in producing novel metabolites for exploitation in medicine. Cytotoxic and antibacterial activities of a total of 300 endophytic fungi were investigated. Endophytic fungi were isolated from various parts of 43 plants from the National Park Pahang, Malaysia. Extracts from solid state culture were tested for cytotoxicity against a number of cancer cell lines using the MTT assay. Antibacterial activity was determined using the disc diffusion method. A total of 300 endophytes were isolated from various parts of plants from the National Park, Pahang. 3.3% of extracts showed potent (IC50 < 0.01 microg/ml) cytotoxic activity against the murine leukemic P388 cell line and 1.7% against a human chronic myeloid leukemic cell line K562. Sporothrix sp. (KK29FL1) isolated from Costus speciosus showed strong cytotoxicity against colorectal carcinoma (HCT116) and human breast adenocarcinoma (MCF7) cell lines with IC50 values of 0.05 microg/ml and 0.02 microg/ml, respectively. Antibacterial activity was demonstrated for 8% of the extracts. Results indicate the potential for production of bioactive agents from endophytes of the tropical rainforest flora.

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Citations

Jan 24, 2013·The Journal of Antibiotics·Shao-Wei LiuCheng-Hang Sun
Sep 29, 2011·BMC Complementary and Alternative Medicine·Azzeme HarunKalavathy Ramasamy
May 17, 2014·Journal of Materials Science. Materials in Medicine·R K MishraA B A Majeed
Mar 9, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nurul Aqmar Mohamad Nor HazalinAbu Bakar Abdul Majeed
Oct 20, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nataša Radić, Borut Strukelj
Jan 25, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Latifah Robbaniyyah HassanAmalina Mohd Tajuddin
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noha FathallahOsama Salama
Mar 8, 2021·Archives of Microbiology·Adekunle Raimi, Rasheed Adeleke

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