Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii

Bioorganic & Medicinal Chemistry Letters
Manh Tuan HaByung Sun Min

Abstract

A phytochemical investigation into the bark of Erythrophleum fordii yielded four new compounds, two new cassaine diterpenoids (erythrofordin T and U, 1 and 2) and two new cassaine diterpenoid amines (erythroformine A and B, 6 and 7), as well as nine known compounds. We report for the first time the isolation of erythrofordin V (3) from a natural source and that of the remaining eight known diterpenoids (4-5, 8-13) from E. fordii. All structures were elucidated using spectroscopic analysis. Cytotoxic activity of the isolated compounds (1-13) was examined in vitro against three non-small cell lung cancer cell lines (A549, NCI-H1975, and NCI-H1229) using the MTT assay. Cassaine diterpene amines (6-10, 12, 13) exhibited potent cytotoxic activity against all three cell lines with IC50 values between 0.4μM and 5.9μM. Erythroformine B (7) significantly induced apoptosis in all three cancer cells in a concentration-dependent manner.

Citations

Aug 17, 2019·Natural Product Reports·James R HansonMark C Bagley
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tu Thanh Thi NguyenManh Hung Tran
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cédric DelporteFlorence Souard
Jan 27, 2019·Journal of Chemical Information and Modeling·Thi Chinh NgoDuy Quang Dao

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