Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword

Free Radical Research
Naoko SugaYoji Kato

Abstract

Serotonin (5-hydroxytryptamine) is a putative substrate for myeloperoxidase, which may convert it into the reactive quinone tryptamine-4,5-dione (TD). In this study, we found that the viability of human SH-SY5Y neuroblastoma cells treated with 25 μM TD was increased to approximately 117%. On the other hand, the cell viability was significantly decreased by exposure to TD (150-200 μM), with an increase in intracellular reactive oxygen species (ROS). Interestingly, pre-treatment of SH-SY5Y cells with 100 μM TD prevented cell death and suppressed intracellular ROS generation evoked by the addition of hydrogen peroxide (H2O2). Expression of the phase-II antioxidant enzyme NAD(P)H: quinone oxidoreductase 1 and haem oxygenase 1 were upregulated by TD at a concentration of 50-100 μM. Nuclear factor erythroid 2-related factor 2 (Nrf2), the regulator of these enzyme, was translocated from the cytosol to the nucleus by 100 μM TD. In summary, moderate concentrations of TD may increase the self-defence capacity of neuronal cells against oxidative stress.

References

Apr 15, 1991·Biochemical Pharmacology·M Z Wrona, G Dryhurst
Jun 24, 1998·Chemical Research in Toxicology·M Z Wrona, G Dryhurst
Apr 22, 2003·Chemical Research in Toxicology·Monika Z WronaGlenn Dryhurst
Mar 17, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·John Q Liu, Rodney J Folz
Mar 18, 2004·Chemical Research in Toxicology·Xiang-Rong JiangGlenn Dryhurst
Apr 28, 2004·Free Radical Biology & Medicine·Ken ItohMasayuki Yamamoto
May 4, 2004·International Journal of Cancer. Journal International Du Cancer·Akira MurakamiHajime Ohigashi
Jul 17, 2004·Journal of Neurochemistry·Pattie S GreenJay W Heinecke
Aug 8, 2009·Bioscience, Biotechnology, and Biochemistry·Kohta OhnishiAkira Murakami
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Yoshimasa Nakamura, Noriyuki Miyoshi
Apr 7, 2010·Archives of Biochemistry and Biophysics·Albena T Dinkova-Kostova, Paul Talalay
Apr 20, 2010·Archives of Biochemistry and Biophysics·Juergen Arnhold, Joerg Flemmig
Jun 26, 2010·The Journal of Clinical Investigation·Filip K SwirskiMatthias Nahrendorf
Oct 26, 2010·Oxidative Medicine and Cellular Longevity·Sabry M Attia
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne KleijnGiulia Fulci
Jul 12, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Roberta CastinoCiro Isidoro
Oct 18, 2011·Seminars in Cell & Developmental Biology·Irina Kaverina, Anne Straube
Sep 27, 2012·Chemical Research in Toxicology·Yoji KatoAnthony J Kettle
Jul 31, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Dec 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hui DongYang Song
Jul 19, 2014·PloS One·Enrica OlivolaAlessandro Stefani
Jul 25, 2015·Scientific American·Mark P Mattson
Dec 15, 2015·Nature Biotechnology·Jianfeng LuSu-Chun Zhang

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Citations

Dec 7, 2018·Frontiers in Genetics·Yaroslav R EfremovSergey S Bogachev
Jun 13, 2018·Journal of Clinical Biochemistry and Nutrition·Yoji Kato, Naoko Suga
Aug 12, 2021·Journal of Clinical Biochemistry and Nutrition·Naoko SugaYoji Kato

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