Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Y C ChangM Y Chou

Abstract

Betel quid chewing has been linked to oral submucous fibrosis and oral cancer. Cytotoxicity and genotoxicity assays were used to investigate the pathobiological effects of arecoline on cultured human buccal fibroblasts. Arecoline increased double-stranded polynucleic acid at the concentration of 0.1 to 10 micrograms/ml in a concentration-dependent manner. At a concentration higher than 50 micrograms/ml, arecoline was cytotoxic to cultured fibroblasts and the cytotoxicity was dose-dependent. No genotoxicity for arecoline was found even at a concentration of 400 micrograms/ml. On the other hand, 600 micrograms/ml glutathione (GSH) and 200 micrograms/ml glycyrrhizin could prevent the arecoline-induced cytotoxicity. These results indicate that arecoline is a cytotoxic agent and no genotoxicity was found to human buccal fibroblasts. Furthermore, increasing consumption of GSH- and glycyrrhizin-rich foods may reduce the oral diseases associated with betel quid chewing.

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Citations

Feb 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang
Feb 24, 2010·Oral and Maxillofacial Surgery·Punnya V Angadi, Sanjay Rao
Jan 3, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shiuan-Shinn LeeYu-Chao Chang
Nov 5, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang
Oct 9, 2007·The Biochemical Journal·Periathamby Antony RajAndrew R Dentino
Oct 2, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sunil Srichand NichlaniArunprabhu Ganeshan
Jan 29, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shun-Fa YangYu-Chao Chang
Dec 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David GoldenbergChul-So Moon
Apr 24, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Stephen CoxHans Zoellner
Jun 2, 2015·Journal of Maxillofacial and Oral Surgery·Vibha SinghRitesh Srivastava
Dec 23, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Oct 15, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Liping WangZhangui Tang
Apr 4, 2001·Journal of Clinical Periodontology·Y C ChangM Y Chou
Feb 18, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Wan-Chun LiKuo-Wei Chang
Apr 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Oct 25, 2020·Archives of Toxicology·Nuno G OliveiraRicardo Jorge Dinis-Oliveira
Jan 12, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang

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