Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T

The Journal of Antibiotics
Jie BaoHua Zhang

Abstract

Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.

References

Apr 1, 1992·Natural Product Reports·J Rohr, R Thiericke
Sep 1, 1970·The Journal of Antibiotics·W C LiuE Meyers
Feb 3, 2011·The Journal of Antibiotics·Xiao RenHua Zhang
Dec 22, 2011·Natural Product Reports·Madan K KharelJürgen Rohr
Jul 17, 2012·Microbiological Research·Ramesh Subramani, William Aalbersberg
Feb 23, 2017·The Journal of Antibiotics·Xiangcheng ZhuHongbo Huang

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Methods Mentioned

BETA
NMR
glycosylation

Software Mentioned

BLAST

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