Abstract
Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.
References
Apr 1, 1992·Natural Product Reports·J Rohr, R Thiericke
Sep 1, 1970·The Journal of Antibiotics·W C LiuE Meyers
May 10, 2002·Nature·S D BentleyD A Hopwood
Feb 7, 2004·The Journal of Antibiotics·Rajendra P MaskeyHartmut Laatsch
Jan 18, 2005·The Journal of Organic Chemistry·Lili ZhuJürgen Rohr
Apr 20, 2005·The Journal of Antibiotics·Noémi AntalAxel Zeeck
Aug 1, 2008·Journal of Natural Products·Mohamed S AbdelfattahJürgen Rohr
Feb 3, 2011·The Journal of Antibiotics·Xiao RenHua Zhang
Dec 22, 2011·Natural Product Reports·Madan K KharelJürgen Rohr
Feb 7, 2012·Journal of Natural Products·Hongbo HuangJianhua Ju
Jul 5, 2012·Journal of Natural Products·Khaled A ShaabanJürgen Rohr
Jul 17, 2012·Microbiological Research·Ramesh Subramani, William Aalbersberg
May 17, 2013·Apoptosis : an International Journal on Programmed Cell Death·Di GeJunying Miao
Jun 21, 2013·Organic Letters·Yun ZhangJianhua Ju
Feb 23, 2017·The Journal of Antibiotics·Xiangcheng ZhuHongbo Huang
Jul 14, 2017·Frontiers in Microbiology·Dongyang WangWeiming Zhu
Sep 12, 2017·ACS Chemical Biology·Shaimaa M SalemJürgen Rohr
Dec 23, 2017·Applied Microbiology and Biotechnology·Balaji Baburao RathodPrakasham Reddy Shetty
Mar 17, 2018·Fitoterapia·Pan WangHua Zhang
Citations
Nov 22, 2019·Journal of Zhejiang University. Science. B·Zi-Yue LiYong-Quan Li
Aug 21, 2020·Preparative Biochemistry & Biotechnology·Yumei LiLingchao Lu
Jul 30, 2019·International Journal of Microbiology·Periyasamy SivalingamKandasamy Prabakar
Jun 24, 2020·Scientific Reports·Pulak Kumar MaitiSukhendu Mandal
Apr 27, 2021·Journal of Natural Products·Zhuo ShangJie Li
Aug 19, 2021·Scientific Reports·Yumei LiLingchao Lu
Sep 8, 2021·Organic & Biomolecular Chemistry·Dalila IacopiniValeria Di Bussolo