PMID: 2491649Jan 1, 1989Paper

Cytotoxic assay of circulating thyroid peroxidase antibodies

Autoimmunity
P WadeleuxR Winand

Abstract

This study describes an assay for the detection of cytotoxicity for thyroid cells in serum of patients with autoimmune thyroiditis. Quantitative measurement may be performed by DNA or [3H] leucine incorporation determinations. The cytotoxic effect is localized in the gamma-globulin fraction, and is complement-mediated. It is thyroid specific i.e. it is not observed with fibroblasts and patients with other autoimmune diseases (patients with lupus erythematosis or glomerulonephritis) do not have cytotoxic antibodies directed against thyroid cells. The thyroid cytotoxicity is related to the presence of antimicrosomal antibodies and the effect of circulating antibodies is inhibited by human thyroid peroxidase. These results strengthen the possible implication of circulating antithyroid peroxidase antibodies in thyroid damage observed in autoimmune thyroiditis.

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Citations

Jul 24, 2002·Biochemical and Biophysical Research Communications·Stéphanie BlanchinJean Ruf
Mar 1, 1967·European Journal of Biochemistry·J Winand-DevigneC Liébecq
Mar 17, 2005·Journal of Autoimmune Diseases·Damien BressonSylvie Péraldi-Roux
Dec 29, 2000·International Reviews of Immunology·S M McLachlan, B Rapoport
Sep 4, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claus H NielsenLaszlo Hegedüs
Oct 30, 2007·Journal of Neuroimmunology·Stéphanie BlanchinJean Jacques Ballet
Aug 16, 2005·Archives of Biochemistry and Biophysics·Jean Ruf, Pierre Carayon
Dec 13, 2007·The Journal of Clinical Endocrinology and Metabolism·Sandra A RebuffatSylvie Peraldi-Roux

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