Cytotoxic Bagremycins from Mangrove-Derived Streptomyces sp. Q22

Journal of Natural Products
Lei ChenZhizhen Zhang

Abstract

New bagremycins C-E (3-5) and bagrelactone A (6), together with known bagremycins A (1) and B (2), 4-hydroxystyrene (7), and 4-hydroxystyrene 4-O-α-d-galactopyranoside (8), were isolated from a mangrove-derived actinomycete, Streptomyces sp. Q22. Structures of these new compounds were elucidated based on their NMR and HRESIMS spectroscopic data as well as chemical degradation. Bagremycin C (3) is a unique analogue with an N-acetyl-(S)-cysteine moiety, while bagrelactone A (6) represents the first example of this type of bagremycin-derived macrolide. Bagremycin C (3) was active against four glioma cell lines, with IC50 values in the range from 2.2 to 6.4 μM, induced apoptosis in human glioma U87MG cells in a dose- and time-dependent manner, and arrested the U87MG cell cycle at the G0/G1 phase.

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Citations

Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Sep 13, 2018·Marine Drugs·Elena AncheevaPeter Proksch
Dec 26, 2018·Natural Product Research·Sangluo ChenXiao-Yuan Lian
Nov 13, 2018·Natural Product Research·Xiufang ZhangZhizhen Zhang
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jodi Woan-Fei LawLearn-Han Lee
Sep 1, 2020·Journal of Natural Products·Le QinZhizhen Zhang
Oct 5, 2019·Journal of Natural Products·Di ZhangBin Wu
Oct 11, 2017·Journal of Natural Products·Ruimin YangSheng-Xiong Huang
Aug 28, 2021·Biomedicines·Rodion KhotimchenkoYuri Khotimchenko

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