Abstract
New bagremycins C-E (3-5) and bagrelactone A (6), together with known bagremycins A (1) and B (2), 4-hydroxystyrene (7), and 4-hydroxystyrene 4-O-α-d-galactopyranoside (8), were isolated from a mangrove-derived actinomycete, Streptomyces sp. Q22. Structures of these new compounds were elucidated based on their NMR and HRESIMS spectroscopic data as well as chemical degradation. Bagremycin C (3) is a unique analogue with an N-acetyl-(S)-cysteine moiety, while bagrelactone A (6) represents the first example of this type of bagremycin-derived macrolide. Bagremycin C (3) was active against four glioma cell lines, with IC50 values in the range from 2.2 to 6.4 μM, induced apoptosis in human glioma U87MG cells in a dose- and time-dependent manner, and arrested the U87MG cell cycle at the G0/G1 phase.
References
May 1, 1967·Chemical & Pharmaceutical Bulletin·G OtaM Shimizu
Nov 21, 2001·The Journal of Antibiotics·M BertassoH P Fiedler
Apr 4, 2008·Journal of Chemical Ecology·Cecilia SocolskyAlicia Bardon
Feb 20, 2010·Current Pharmaceutical Design·Maria De Falco, Antonio De Luca
Oct 12, 2010·Expert Review of Neurotherapeutics·Marc C Chamberlain
Nov 9, 2011·Biotechnology Letters·Yunxia ZhuHuizhan Zhang
Dec 4, 2012·Marine Drugs·Wenxiu XinZhizhen Zhang
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Oktay TacarCrispin R Dass
Jun 7, 2013·Expert Opinion on Drug Discovery·Shivaputra A PatilDuane D Miller
Jan 11, 2014·Expert Opinion on Therapeutic Patents·Ahmed KamalMohammed Shaheer Malik
Jun 29, 2014·Steroids·Siran YuZhizhen Zhang
Jan 28, 2015·Planta medica·Siran YuZhizhen Zhang
Mar 25, 2015·Microbiological Research·Feng LiuHuizhan Zhang
May 20, 2015·Bioorganic & Medicinal Chemistry Letters·Lu ChenZhizhen Zhang
Jun 30, 2015·Natural Product Research·Xuewei YeZhizhen Zhang
Jan 12, 2016·Marine Drugs·Ying LiangZhizhen Zhang
Mar 8, 2016·Microbiological Research·Rabia TanvirStephanie Grond
Oct 12, 2016·Marine Drugs·Xiufang ZhangZhizhen Zhang
Citations
Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
May 22, 2018·Frontiers in Microbiology·Zhong-Ke JiangCheng-Hang Sun
Sep 13, 2018·Marine Drugs·Elena AncheevaPeter Proksch
Feb 6, 2019·Marine Drugs·Komal AnjumZhizhen Zhang
Aug 15, 2019·MBio·Loïc MartinetSébastien Rigali
Jul 16, 2020·Biomolecules·Loïc MartinetSébastien Rigali
Jan 10, 2018·Scientific Reports·Mengxuan ChenZhizhen Zhang
Sep 15, 2018·Marine Drugs·Di ZhangZhizhen Zhang
Jul 30, 2020·Marine Drugs·Wenwen YiZhizhen Zhang
Dec 26, 2018·Natural Product Research·Sangluo ChenXiao-Yuan Lian
Nov 13, 2018·Natural Product Research·Xiufang ZhangZhizhen Zhang
May 20, 2020·Marine Drugs·Sidra KaleemZhizhen Zhang
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jodi Woan-Fei LawLearn-Han Lee
Sep 1, 2020·Journal of Natural Products·Le QinZhizhen Zhang
Jan 4, 2018·Journal of Natural Products·Yanhui TanXuefeng Zhou
Oct 5, 2019·Journal of Natural Products·Di ZhangBin Wu
Oct 11, 2017·Journal of Natural Products·Ruimin YangSheng-Xiong Huang
Mar 9, 2018·Journal of Natural Products·Xiaowei LuoYonghong Liu
Oct 6, 2018·The Journal of Organic Chemistry·Tengfei SongXiao-Yuan Lian
Aug 28, 2021·Biomedicines·Rodion KhotimchenkoYuri Khotimchenko