Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves

Journal of Natural Products
Sudarat KruakaewSomyote Sutthivaiyakit

Abstract

Thirteen cardenolide glycosides (1-13) were isolated from the CH2Cl2 and MeOH extracts of Vallaris glabra leaves. The structures of the new compounds (2-13) were identified by spectroscopic methods, with the absolute configurations of the sugar moieties determined by acid hydrolysis. All compounds were evaluated for their cytotoxic activity against human cervix adenocarcinoma, lung carcinoma, and colorectal adenocarcinoma cell lines. The two most potent compounds [2'-O-acetylacoschimperoside P (1) and oleandrigenin-3-O-α-l-2'-O-acetylvallaropyranoside (2)] exhibited IC50 values in the range of 0.03-0.07 μM.

References

Mar 1, 1990·Chemical & Pharmaceutical Bulletin·T Yamauchi, F Abe
Jan 9, 2003·Journal of Agricultural and Food Chemistry·Sugunya WongpornchaiSuppachai Choonvisase
Feb 26, 2005·Journal of Natural Products·Liwei FuMasayoshi Ando
Jun 1, 2011·Journal of Natural Medicines·Yusnita RifaiMasami Ishibashi
Jan 17, 2012·Fitoterapia·Angela PerroneSonia Piacente
Feb 6, 2014·Pharmacognosy Research·Siu Kuin WongEric Wei Chiang Chan

❮ Previous
Next ❯

Citations

Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin
Jun 18, 2021·Organic Letters·Ayham H AbazidBoris J Nachtsheim
Dec 11, 2019·Journal of Natural Products·Sudarat KruakaewSomyote Sutthivaiyakit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Related Papers

Chemical & Pharmaceutical Bulletin
Akihito YokosukaYoshihiro Mimaki
Natural Product Communications
Hoang Le Tuan AnhPhan Van Kiem
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jie MaDong-Ming Zhang
© 2022 Meta ULC. All rights reserved