Abstract
Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.
References
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Jul 3, 1998·Journal of Women's Health·S Lieberman
Aug 5, 2000·Journal of Natural Products·Y ShaoE Lemmo
May 26, 2001·Journal of Natural Products·N ZhuC T Ho
Apr 27, 2002·Journal of Natural Products·Shao-Nong ChenNorman R Farnsworth
Oct 26, 2002·Journal of Natural Products·Shao-Nong ChenNorman R Farnsworth
May 11, 2004·Chemical & Pharmaceutical Bulletin·Liang ZhouGuangZhong Tu
Nov 23, 2005·Fitoterapia·Ze TianPei Gen Xiao
Aug 15, 2006·Phytotherapy Research : PTR·Minghua QiuByung-Sun Min
Oct 28, 2006·Journal of Natural Products·Jingchun GaoPeigen Xiao
Jan 27, 2007·Journal of Natural Products·Zulfiqar AliIkhlas A Khan
Jan 30, 2007·Planta medica·W YeS Zhao
Sep 21, 2007·Journal of Ethnopharmacology·Ze TianErxi Wu
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lirong SunMinghua Qiu
Citations
Apr 30, 2013·Journal of Natural Products·Yin NianMing-Hua Qiu
Jun 3, 2014·Fitoterapia·Ni-Man BaoMing-Hua Qiu
Jan 14, 2016·Chinese Medicine·Hai-Yan SunSi-Bao Chen
Mar 8, 2011·Phytochemistry·Derya GülcemalErdal Bedir
Jul 10, 2012·Journal of Ethnopharmacology·Yun-Yun GaiJing-Kai Gu
Feb 12, 2017·International Journal of Biological Macromolecules·Nguyen Phuong ThaoYoung Ho Kim
May 22, 2016·Natural Products and Bioprospecting·Guo-Lei ZhuMing-Hua Qiu
Jul 7, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Rong SunMing-Hua Qiu
Mar 13, 2015·Scientific Reports·Yin NianMing-Hua Qiu
May 18, 2012·Natural Product Reports·Robert A Hill, Joseph D Connolly
Jun 13, 2012·Chemical & Pharmaceutical Bulletin·Lu LuMing-Hua Qiu
Jun 6, 2020·Natural Product Research·Qiang-Qiang ShiMing-Hua Qiu
Jul 17, 2018·Journal of Natural Products·Abdul RahimKyoko Nakagawa-Goto
Aug 20, 2014·Journal of Natural Products·Ji-Yong ChenGuo-Qiang Li
Aug 17, 2021·Frontiers in Chemistry·Meigeng HuXi Chen
Jul 26, 2018·The Journal of Organic Chemistry·Qiang-Qiang ShiMing-Hua Qiu