Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected

Journal of Natural Products
Yin NianChen Qing

Abstract

Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.

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Citations

Mar 8, 2011·Phytochemistry·Derya GülcemalErdal Bedir
May 22, 2016·Natural Products and Bioprospecting·Guo-Lei ZhuMing-Hua Qiu
Jul 7, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Rong SunMing-Hua Qiu
May 18, 2012·Natural Product Reports·Robert A Hill, Joseph D Connolly
Jul 17, 2018·Journal of Natural Products·Abdul RahimKyoko Nakagawa-Goto
Aug 20, 2014·Journal of Natural Products·Ji-Yong ChenGuo-Qiang Li
Jul 26, 2018·The Journal of Organic Chemistry·Qiang-Qiang ShiMing-Hua Qiu

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