PMID: 16526277Mar 11, 2006Paper

Cytotoxic constituents from Solanum lyratum

Archives of Pharmacal Research
Li-Xin SunMin-Wei Wang

Abstract

Activity-guided fractionation of the ethanol extract of the whole plant from Solanum lyratum resulted in the isolation of a new pregnane derivative glycoside, 16-dehydropregnenolone 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosid uronic acid (2), as well as other six known compounds: 16-dehydropregnenolone (1), allopregenolone (3), protocatechuic acid (4), vanillic acid (5), caffeic acid (6), and scopoletin (7). The structures of the isolated compounds were elucidated on the basis of their spectral data and chemical evidences. Compounds 1, 3, 4 were isolated for the first time from this plant. Cytotoxic activities of the isolated compounds were evaluated. Compound 1 exhibited significant cytotoxic activity against A375-S2, HeLa, SGC-7901, and Bel-7402 with IC50 values of 13.1 +/- 0.9, 21.5 +/- 1.0, 40.2 +/- 0.7, and 49.8 +/- 1.2 microg/mL, respectively.

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Citations

Apr 28, 2010·Archives of Pharmacal Research·Seung Young LeeKang Ro Lee
Apr 6, 2012·Archives of Pharmacal Research·Seung Young LeeKang Ro Lee
Jun 15, 2012·Journal of Asian Natural Products Research·En-Long MaLi-Xin Sun
May 23, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jai-Sing YangJing-Gung Chung
Mar 4, 2010·Human & Experimental Toxicology·Jai-Sing YangJing-Gung Chung
Mar 15, 2019·Natural Products and Bioprospecting·Joseph Sakah Kaunda, Ying-Jun Zhang
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Teeratas KijpornyongpanChanpen Chanchao

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