Cytotoxic constituents of roots of Chaerophyllum hirsutum

Journal of Natural Products
Stefano Dall'AcquaGabbriella Innocenti

Abstract

Two new lignan derivatives (1 and 2), along with the known scopoletin (3), methyl caffeate (4), falcarindiol (5), 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic methyl ester, chlorogenic acid, p-hydroxyphenylethyl-trans-ferulate, and vanillin, were isolated from extracts of the roots of Chaerophyllum hirsutum. Structure elucidation of the new compounds was carried out by 1D and 2D NMR experiments and by HRMS analysis. Several of the isolated compounds were tested for their cytotoxic activity against the HL-60, HT-1080, LoVo, and LoVo/Doxo cell lines.

References

Jan 1, 1988·Chemical & Pharmaceutical Bulletin·M NishizawaY Fujimoto
Feb 24, 2001·Bioorganic & Medicinal Chemistry·B EtzenhouserC D Selassie
Feb 24, 2001·Phytochemistry·M del Rayo CamachoP N Solis

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Citations

Mar 30, 2011·Journal of Natural Products·Prapairat SeephonkaiBrigitte Kopp
Oct 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mansour ZnatiJalloul Bouajila
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lars Porskjær Christensen
Jul 12, 2012·Chemistry & Biodiversity·Niko S RadulovićNevenka D Ethorđević
Nov 10, 2020·Chemical Reviews·Gina PorrasCassandra L Quave
Feb 24, 2015·Organic Letters·Scott W Krabbe, Jeffrey S Johnson
Jul 16, 2014·Journal of Agricultural and Food Chemistry·Ki Hyun KimKang Ro Lee

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