PMID: 11908960Mar 23, 2002Paper

Cytotoxic constituents of the stem bark of Neolitsea acuminatissima

Journal of Natural Products
Fang-Rong ChangYang-Chang Wu

Abstract

Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.

References

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Citations

May 13, 2008·Journal of Asian Natural Products Research·Li-Ping ZhuDong-Ming Zhang
Jul 6, 2005·Chemical & Pharmaceutical Bulletin·Yann-Lii LeuLi-Shian Shi
Jul 12, 2016·Natural Product Research·Qiang-Qiang LuJin-Ming Gao
Nov 13, 2010·Chemistry & Biodiversity·Yu-Fang WangHiromasa Kiyota
Oct 16, 2015·Chemistry & Biodiversity·Yuan CaoXing-Yun Chai
Jan 21, 2014·Chemistry & Biodiversity·Wan-Ying WangPei-Gen Xiao
Apr 1, 2016·Journal of Food and Drug Analysis·Hsun-Shuo Chang, Ih-Sheng Chen
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley
Aug 7, 2017·Journal of Immunology Research·Yin-Hua ChengChia-Chi Wang
Nov 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chu-Hung LinHorng-Huey Ko
Apr 16, 2021·The Journal of Organic Chemistry·Yao-Yue FanJian-Min Yue
Dec 30, 2009·Journal of Natural Products·Xiu-Feng HeJian-Min Yue
Jul 29, 2008·Journal of Agricultural and Food Chemistry·Young-Won ChinA Douglas Kinghorn

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