Cytotoxic diterpene quinones from Salvia tebesana Bunge

Fitoterapia
Samira EghbaliferizJavad Asili

Abstract

A phytochemical investigation of the root extracts of Salvia tebesana Bunge led to the isolation of two new diterpenoids, tebesinone A (1) and tebesinone B (2), along with two known compounds, aegyptinone A (3) and aegyptinone B (4). The structures were established by spectroscopic analysis including 1D and 2D NMR and HRESIMS. The cytotoxic activities of the crude extracts and isolated compounds were evaluated against MCF-7, B16F10, PC-3 and C26 human cancer cell lines, in which compounds 2 and 3 showed significant cytotoxic activities (IC50 2.1-10.3 μM).

Citations

Jun 27, 2020·International Journal of Molecular Sciences·Sylwester ŚlusarczykAdam Matkowski
Sep 17, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Abolfazl ShakeriJavad Asili
Aug 14, 2019·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Samira EghbaliferizJavad Asili
Dec 30, 2020·Phytochemistry·Sayyedeh Fatemeh AskariSamira Eghbali
Mar 19, 2020·Anti-cancer Agents in Medicinal Chemistry·Jana WiemannRené Csuk

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