PMID: 70278Jul 1, 1977Paper

Cytotoxic effect of a reverse transcriptase inhibitor, AF/ABDP cis, on ovaries of young Xenopus laevis--ultrastructural and autoradiographic study

Chemico-biological Interactions
M Steens

Abstract

Observations with the light and electron microscopes showed that a reverse transcriptase inhibitor, AF/ABDP cis which is a rifampicin derivative, had a toxic effect on ovaries of young Xenopus laevis. It induced mitochondrial damage in all observed cells and marked alteration of the ultrastructure of nucleus of the pachytene oocyte. Light autoradiography showed that AF/ABDP cis caused wide variation in nuclear labelling with [3H] thymidine from one pachytene oocyte to another. Somatic cells were more uniformly labelled. These results are discussed in relation to the interpretation experiments upon eucaryote cells in which this drug is used as a reverse transcriptase inhibitor.

References

Jan 1, 1972·Annual Review of Microbiology·S Riva, L G Silvestri
Mar 1, 1972·The Journal of Cell Biology·L W Coggins, J G Gall
Jan 1, 1971·Chromosoma·A P Bird, M L Birnstiel
Jun 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J G Gall
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M Crippa, G P Tocchini-Valentini
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A Ficq, J Brachet
Mar 25, 1958·The Journal of Biophysical and Biochemical Cytology·A M GLAUERT, R H GLAUERT

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