Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

Toxicology Research
Yuexiang NiuQingan Zhang

Abstract

Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO2) towards cancer cells has been reported previously, but the specific mechanism is not fully clear. In this study, Nano-SiO2 showed a remarkable cytotoxic effect against HCC cells, regardless of whether the cells were drug resistant or not. Further study showed that Nano-SiO2 treatment leads to cell cycle arrest, apoptosis enhancement and necroptosis induction in the HCC cells. RNA-seq data, together with bioinformatics analysis, revealed that a series of genes involved in cancer cell death could be regulated by Nano-SiO2, among which ZBP-1 was up-regulated the most by Nano-SiO2 treatment. The siRNA based experiments demonstrated that ZBP-1 might play a key role in mediating Nano-SiO2 cytotoxic functions against HCC cells. These results have evidently signified the anti-tumor potential of Nano-SiO2 in the treatment of HCC.

References

Jul 2, 2005·World Journal of Gastroenterology : WJG·Zi-Li LüJian-Ming Wen
Jan 12, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yiyi YeMinbo Lan
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 31, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·In-Yong KimKyekyoon Kim
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zahra ShahsavariSiamak Salami
Dec 27, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Yannan Yang, Chengzhong Yu
Nov 8, 2016·Nature·Juan LinManolis Pasparakis
Dec 14, 2016·Annual Review of Pathology·Lorenzo GalluzziGuido Kroemer
Mar 12, 2017·International Journal of Environmental Research and Public Health·Collins Otieno AswetoZhiwei Sun
Sep 2, 2017·International Journal of Nanomedicine·Shijie LiHui Sun
May 29, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yeonhwa SongHaeng Ran Seo
Nov 24, 2018·Frontiers in Bioscience (Landmark Edition)·Lucas TricoliDeepak Kumar

❮ Previous
Next ❯

Citations

Jul 20, 2020·Environmental Science and Pollution Research International·Mohammad-Reza SepandNima Sanadgol
Jul 6, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohammad Reza SepandMohammad Raoufi
Aug 30, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Keenan J Mintz, Roger M Leblanc

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
electrophoresis
flow cytometry
RNA-seq

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.