Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids

Bioorganic & Medicinal Chemistry Letters
T S KamKanki Komiyama

Abstract

A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.

References

Dec 29, 2006·Chemistry & Biodiversity·Toh-Seok KamKanki Komiyama

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Citations

Sep 10, 2008·Journal of Natural Products·Kuan-Hon LimToh-Seok Kam
Feb 19, 2016·The Journal of Pharmacy and Pharmacology·Ibrahim Babangida Abubakar, Hwei-San Loh
Feb 17, 2009·Phytochemistry·Kuan-Hon LimToh-Seok Kam
Nov 22, 2007·Journal of Ethnopharmacology·Kenneth R AlperCharles D Kaplan
Feb 1, 2013·Pharmaceutical Biology·Kirankumar HullattiMahesh Biradi
Jun 28, 2016·Angewandte Chemie·Wiktoria H PaceLaura L Anderson
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saikat DewanjeeMuhammad Zia-Ul-Haq
Jan 20, 2007·Phytotherapy Research : PTR·C BayetD Guilet
Sep 13, 2013·Anti-cancer Drugs·Wen-Tai LiChiung-Tong Chen
Sep 25, 2020·Angewandte Chemie·Atsushi NakayamaKosuke Namba
Sep 1, 2018·Journal of Natural Products·You-Sheng CaiSheng-Ping Yang

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