PMID: 11909641Mar 23, 2002Paper

Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity

Biochimica Et Biophysica Acta
Maria P M MarquesP Garcia

Abstract

Cytotoxicity and cell growth inhibition studies were performed for three distinct polynuclear platinum(II) complexes of spermidine, which showed to have significant cytotoxic and antiproliferative properties on the HeLa cancer cell line. The chemical environment of the metal centres in the drugs, as well as the coordination pattern of the ligand, were found to be strongly determinant of their cytotoxic ability. In the light of the results gathered, the most effective anticancer compound among the ones tested (IC50=5 microM) was found to be the one displaying three difunctional (PtCl2N2) moieties ((PtCl2)3(spd)2). Both the cytotoxic activity and the antiproliferative properties of the complexes studied showed to be irreversible for all the concentrations tested.

Citations

Dec 17, 2009·Amino Acids·E AgostinelliA Toninello
May 25, 2012·Applied Biochemistry and Biotechnology·Reza YousefiMohammad Mehdi Papari
Feb 23, 2010·Plant Physiology and Biochemistry : PPB·Annalisa TassoniDonatella Serafini-Fracassini
Mar 5, 2011·Chemical Biology & Drug Design·Sónia M FiuzaMaria P M Marques
Jul 28, 2004·Biochimica Et Biophysica Acta·Agnieszka StachurskaBarbara Grzelakowska-Sztabert
Nov 21, 2007·The Journal of Chemical Physics·Ana M AmadoLuis A E Batista de Carvalho
Dec 3, 2016·Physical Chemistry Chemical Physics : PCCP·M P M MarquesL A E Batista de Carvalho
Jan 21, 2015·Physical Chemistry Chemical Physics : PCCP·M Paula M MarquesLuis A E Batista de Carvalho
Jan 19, 2019·Physical Chemistry Chemical Physics : PCCP·Ana L M Batista de CarvalhoM Paula M Marques
Apr 28, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Luís A E Batista de CarvalhoJohn Tomkinson
Mar 21, 2007·Biochemical Society Transactions·M P M Marques, L A E Batista de Carvalho
May 5, 2018·Acta Crystallographica. Section C, Structural Chemistry·A L M Batista de CarvalhoM P M Marques
Jan 15, 2005·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ana M AmadoLuis A E Batista de Carvalho
Jul 25, 2019·The Journal of Physical Chemistry. B·Maria Paula M MarquesLuís A E Batista de Carvalho
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana S MartinsAna M Gil

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