PMID: 3756208Oct 1, 1986Paper

Cytotoxic effects of paraquat and inhibition of them by vitamin E

Biochimica Et Biophysica Acta
N WatanabeS Yoshida

Abstract

Paraquat causes failure of multiple organs including the liver in humans. The kinetics and mechanism of paraquat intoxication were studied using cultured rat hepatocytes. Paraquat induced time- and dose-dependent lactate dehydrogenase release, lipid peroxidation, and cell death, estimated as decrease in protein in cells attached to culture dishes. However, the increase in lipid peroxidation occurred after lactate dehydrogenase release had reached a plateau. Vitamin E inhibited the inductions of all these cytotoxic effects of paraquat. Kinetic studies showed that lipid peroxidation was a better indicator of cell death than lactate dehydrogenase release, because vitamin E inhibited the induction of cell death even when added 6 h after paraquat, when lactate dehydrogenase release had reached a plateau but lipid peroxidation had not. The present results strongly suggest that paraquat exerts its cytotoxicity by a mechanism involving oxidation reactions.

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Citations

May 7, 2002·Toxicology Letters·Akram RanjbarMohammad Abdollahi
Jul 1, 2002·Environmental Health and Preventive Medicine·Tetsuhito FukushimaMasaki Moriyama
Mar 26, 2013·PloS One·Mohamed Abdelmonem FahimMohamed Yousif Hasan
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Dec 11, 1992·Toxicology and Applied Pharmacology·J W BaumanC D Klaassen
Nov 17, 2015·Iranian Red Crescent Medical Journal·Mohammad Ali DavarpanahS Saeed Mohammadi
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Apr 26, 1995·Biochimica Et Biophysica Acta·C M PalmeiraV M Madeira
Nov 1, 1987·Chemistry and Physics of Lipids·G PoliM U Dianzani

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