PMID: 6090360Sep 1, 1984

Cytotoxic effects of WR-2721 on mouse testicular cells

International Journal of Radiation Oncology, Biology, Physics
M L MeistrichL Milas

Abstract

WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) has been demonstrated to be cytotoxic to stem spermatogonia in the mouse. Five and 10 injections of 300 mg/kg killed sufficient numbers of stem cells to reduce sperm production 56 days after treatment by 16 and 43%, respectively. Single injections of 300 or 400 mg/kg of WR-2721 given 15 min after irradiation produced negligible toxicity to stem cells as measured by counts of repopulated tubules; 600 mg/kg reduced stem cell survival by 47%. Four daily injections of 300 mg/kg given 4, 3, 2, and 1 days prior to irradiation (with or without a fifth injection 15 min after irradiation) reduced stem cell survival by about 60%. The cytotoxic effects of WR-2721 on testicular stem cells at least partially explains the reduced protection factors observed in the testis with low doses of radiation and during fractionated treatments involving multiple injections of drug.

References

Citations

Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Basic
Jan 13, 2010·Reproductive Biology and Endocrinology : RB&E·Vanessa VendraminiSandra M Miraglia
Oct 25, 2013·International Journal of Biological Sciences·Liren QianJianming Cai
May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Kiss
Nov 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M L MeistrichL Milas
Feb 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A Kanclerz, J D Chapman
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·E L Travis
Nov 1, 1986·International Journal of Radiation Oncology, Biology, Physics·S L McChesneyS J Withrow
Jan 2, 2014·Spermatogenesis·Kar Wah Leung, Alice St Wong
Apr 1, 1991·International Journal of Radiation Biology·G J van den AardwegA B Nethersell

Related Concepts

Cell Survival
Dose-Response Relationship, Radiation
Ethyol
Mice, Inbred C3H
Organothiophosphorus Compounds
Radiation-Protective Effect
Specific Pathogen Free
Spermatogonia
Y-Chromosome-Bearing Sperm
Colony-forming Unit

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