Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilio

Planta medica
Mehrdad IranshahiRonald J Quinn

Abstract

A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11- β-methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC (50) = 8.83 ± 1.87 µM) and NFF (0.64 ± 0.37 µM) cell lines.

Citations

Feb 16, 2019·Phytotherapy Research : PTR·Douglas F RamboAmélia T Henriques
Jun 23, 2019·Natural Product Research·Nouran M FahmyAbdel Nasser Singab
Feb 12, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Shuping ShuaiLiming Ye
Jun 20, 2021·Bioorganic & Medicinal Chemistry Letters·Murilo K A YonekawaEdson Dos A Dos Santos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.