Cytotoxic evaluation of injectable cyclodextrin nanoparticles

The Journal of Pharmacy and Pharmacology
Erem Memisoglu-BilensoyA Atilla Hincal

Abstract

Nanoparticles were prepared using beta-CDC6, which is an amphiphilic beta-cyclodextrin derivative modified on the secondary face with 6C aliphatic esters. A nanoprecipitation technique was used to prepare the blank nanoparticles without any surfactant and nanoparticles containing Pluronic F68 as surfactant in a concentration range of 0.1 to 1%. Nanoparticle formulations were characterized by particle size distribution and zeta potential measurements. Entrapment efficiency and in-vitro release profiles were determined and the cytotoxicity of these injectable nanospheres was evaluated against mouse fibroblast L929 cell line and human polymorphonuclear cells by methlythiazolyltetrazolium assay. As far as particle size and zeta potential are concerned, there is a relationship between surfactant presence and nanoparticle characteristics. However, these effects are not significant. It was also found that surfactant presence has no effect on model drug nimodipine encapsulation but accelerates the in-vitro release of the drug. Cell culture studies on mouse fibroblasts and human polymorphonuclear cells revealed a concentration-dependent cytotoxicity more pronounced in fibroblast cells. This led to the conclusion that the use of surfacta...Continue Reading

References

Jan 25, 1985·The American Journal of Cardiology·H J Gelmers
Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Feb 1, 1997·Journal of Pharmaceutical Sciences·T Irie, K Uekama
Jan 1, 1995·Critical Reviews in Therapeutic Drug Carrier Systems·E Albers, B W Müller
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D DuchêneG Ponchel
Dec 14, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M D Veiga, F Ahsan
Jun 6, 2000·Advanced Drug Delivery Reviews·V J StellaV Zia
Feb 19, 2002·Chemical Reviews·József Szejtli
Aug 29, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·Patrick CouvreurChristine Vauthier
Jan 16, 2003·International Journal of Pharmaceutics·Erem MemişoğluA Atilla Hincal
Mar 1, 2003·Pharmaceutical Research·Erem MemişoğluA Atilla Hincal

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Citations

Sep 19, 2012·Inorganic Chemistry·Christian N GaronFrédéric-Georges Fontaine
Nov 30, 2011·TheScientificWorldJournal·David M GoncalvesDenis Girard
Sep 11, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Josias B G YaméogoDenis Wouessidjewe
Jul 2, 2014·Nanomedicine·Jaya Raju Lakkakula, Rui Werner Maçedo Krause
Mar 6, 2012·Journal of Liposome Research·Jaleh VarshosazMostafa Khadem
Aug 27, 2009·Expert Opinion on Drug Delivery·Erem Bilensoy, A Atilla Hincal
Aug 19, 2007·International Journal of Pharmaceutics·A GèzeD Wouessidjewe
Aug 11, 2007·International Journal of Pharmaceutics·Erem BilensoyA Atilla Hincal
Mar 1, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Feng-Lin YenChun-Ching Lin
Sep 14, 2017·Beilstein Journal of Nanotechnology·Gamze VaranErem Bilensoy
May 7, 2020·Advanced Pharmaceutical Bulletin·Dipak Dilip Gadade, Sanjay Sudhakar Pekamwar
Jan 14, 2009·Inorganic Chemistry·Christian N GaronFrédéric-Georges Fontaine

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