Cytotoxic immune response of meningioma patients towards allogeneic and autologous tumour cells before and after surgery

Acta neurochirurgica
H W Pees

Abstract

Cell-mediated cytotoxicity (CTX) of meningioma patients towards meningioma cells and fibroblasts was studied in vitro before and after surgery, using the 3H-proline microcytotoxicity test. When incubated with allogeneic target cells before surgery, lymphocytes from three out of seven donors showed a specific destruction of meningioma tissue, and two were cytotoxic on both types of targets. Five patients were tested against their own tumour and against skin fibroblasts; this was feasible by keeping their lymphocytes frozen in liquid nitrogen until their target cells grew as suitable monolayers in vitro. Three patients showed a specific cytotoxic response. After excision of the tumour a gradual loss of this reactivity was observed in both allogeneic and autologous systems. Sera of three patients, whose lymphocytes were not reactive against their own tumour, induced antibody-dependent cellular cytotoxicity (ADCC) towards autologous tumours if normal effector cells were used. This type of response was detectable mainly in postoperative sera, and could not be elicited in autologous lymphocytes. On the contrary, autologous sera inhibited CTX of meningioma effector cells. The data suggest that meningiomas can induce a complex immunolo...Continue Reading

References

Jan 1, 1978·Current Topics in Microbiology and Immunology·G R Pearson
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·G B CannonR B Herberman
Oct 2, 1975·The New England Journal of Medicine·R A Fishman
Jul 15, 1972·International Journal of Cancer. Journal International Du Cancer·C O'TooleF Edsmyr
Sep 1, 1973·Cryobiology·R L PowlesC K Grant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Mehmet Turgut
Journal of Neurosurgery
James B Elder, E Antonio Chiocca
Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing
K Gross, C Payne
Nō to shinkei = Brain and nerve
K Sano
© 2021 Meta ULC. All rights reserved