Cytotoxic Immunity in Peripheral Nerve Injury and Pain

Frontiers in Neuroscience
Alexander J DaviesSeog Bae Oh

Abstract

Cytotoxicity and consequent cell death pathways are a critical component of the immune response to infection, disease or injury. While numerous examples of inflammation causing neuronal sensitization and pain have been described, there is a growing appreciation of the role of cytotoxic immunity in response to painful nerve injury. In this review we highlight the functions of cytotoxic immune effector cells, focusing in particular on natural killer (NK) cells, and describe the consequent action of these cells in the injured nerve as well as other chronic pain conditions and peripheral neuropathies. We describe how targeted delivery of cytotoxic factors via the immune synapse operates alongside Wallerian degeneration to allow local axon degeneration in the absence of cell death and is well-placed to support the restoration of homeostasis within the nerve. We also summarize the evidence for the expression of endogenous ligands and receptors on injured nerve targets and infiltrating immune cells that facilitate direct neuro-immune interactions, as well as modulation of the surrounding immune milieu. A number of chronic pain and peripheral neuropathies appear comorbid with a loss of function of cellular cytotoxicity suggesting such ...Continue Reading

References

Sep 1, 1992·The Journal of Experimental Medicine·W F HickeyR E Schmidt
Jun 1, 1991·Journal of the Neurological Sciences·W Brück, R L Friede
Jan 1, 1991·Pain·J C Liebeskind
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jan 1, 1986·Journal of Clinical Immunology·B A BlazarJ A Mannick
Sep 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N K CheungN A Berger
Jan 1, 1985·Annual Review of Immunology·P A Henkart
Mar 1, 1981·The Journal of Experimental Medicine·T TimonenR B Herberman
Nov 1, 1983·Scandinavian Journal of Immunology·H J AarstadR Seljelid
Jul 1, 1995·The American Journal of Medicine·D LeitenbergB R Smith
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·P G FarlieO Bernard
Oct 1, 1994·The European Journal of Neuroscience·F GillardonM Zimmermann
Sep 1, 1993·Neurology·D H Bobker, T G Deloughery
Jun 10, 1998·Journal of the Neurological Sciences·F Yoshii, Y Shinohara
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·S Ben-EliyahuG Shakhar
Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·H P Hartung
Oct 16, 1999·British Journal of Haematology·G R RabbaniA Tefferi
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M DavisJ L Strominger
Jun 8, 2000·The Journal of Comparative Neurology·T TandrupR E Coggeshall
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E BackströmH G Ljunggren
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey

❮ Previous
Next ❯

Citations

Feb 10, 2021·International Journal of Molecular Sciences·Petra BaumJoanna Kosacka
Nov 14, 2020·Biology of Sex Differences·Katja Linher-MelvilleGurmit Singh
Jan 17, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Lucía Martínez Cuesta, Sandra Elizabeth Pérez
Oct 15, 2020·Cells·James MeixiongHao-Jui Weng
May 26, 2020·Pharmacology & Therapeutics·Bao-Chun JiangYong-Jing Gao
Mar 25, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary F BarbeMichael R Ruggieri
Oct 16, 2020·Journal of Reconstructive Microsurgery·Jonathan LansKyle R Eberlin
Mar 27, 2021·Pain·Josephine LassenPhilipp Hüllemann
Oct 2, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Peter Arthur-Farraj, Michael P Coleman

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation
biopsy
biopsies

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Current Topics in Microbiology and Immunology
Donghoon KimSung Joong Lee
Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Petr Dubový
Experimental Neurology
Maria Fitzgerald, Rebecca McKelvey
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Rebecca McKelveyMaria Fitzgerald
© 2021 Meta ULC. All rights reserved