Cytotoxic macrocyclic diterpenoids from Jatropha multifida

Bioorganic Chemistry
Jun-Sheng ZhangSheng Yin

Abstract

Nine new macrocyclic diterpenoids (1-9), jatromultones A-I, along with eight known analogues (10-17) were isolated from the trunks of Jatropha multifida. The structures of the new compounds, including their absolute configurations, were elucidated by combination of spectroscopic analysis, single crystal X-ray diffraction, Rh2(OCOCF3)4-induced CD method, and chemical correlations. All compounds were screened for the cytotoxicity against five cancer cell lines, including one drug-resistant cell line, and seven compounds exhibited significant activity with IC50 values less than 10 μM. Compound 4 with IC50 values ranging from 2.69 to 6.44 μM toward all cell lines was selected for further mechanistic study, which showed that 4 could arrest cell cycle at G2/M phase and induce apoptosis. The brief structure-activity relationships (SARs) of these macrocyclic diterpenoids were also discussed.

Citations

May 24, 2019·Journal of Asian Natural Products Research·Zhao YinWei Li
Apr 16, 2020·Journal of Asian Natural Products Research·Ming-Feng ZouSheng Yin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Qian SunShao-Jiang Song
Journal of Natural Products
Shi-Hui DongJian-Min Yue
Chemical & Pharmaceutical Bulletin
Zhuo HuJian-Xin Pu
Journal of Natural Products
Shanshan LiuLijiang Xuan
© 2022 Meta ULC. All rights reserved