Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum

Journal of Natural Products
Liyuan LiTian Jiao Zhu

Abstract

Two new epipolythiodioxopiperazines, named chetracins B and C (1 and 2), and five new diketopiperazines, named chetracin D (4) and oidioperazines A-D (5, 10, 12, and 13), were isolated from the fungus Oidiodendron truncatum GW3-13, along with six known compounds (3, 6, 7, 8, 9, and 11). Their structures were elucidated by extensive NMR, MS, and CD analyses, as well as chemical transformation. An in vitro MTT cytotoxicity assay revealed potent biological activity for 1 in the nanomolar range against a panel of five human cancer lines.

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Citations

Jul 5, 2013·Journal of Asian Natural Products Research·Chun-Chi FengHao Gao
Mar 5, 2013·Journal of the American Chemical Society·Salman Y Jabri, Larry E Overman
May 5, 2016·Extremophiles : Life Under Extreme Conditions·Zhuang DingTianjiao Zhu
Jun 2, 2016·Journal of Asian Natural Products Research·Ting ZhangTian-Jiao Zhu
Jul 1, 2016·Journal of Natural Products·Haibo ZhouDehai Li
Mar 30, 2017·Organic Letters·Haoxuan WangSarah E Reisman
Nov 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohan WangLigang Zhou
Mar 31, 2018·Natural Product Research·Cong-Cong LiuTian-Jiao Zhu
Jul 8, 2015·Natural Product Reports·Minoru IshikuraSatoshi Hibino
Jul 17, 2019·Journal of Applied Microbiology·A M SayedM E Rateb
Jul 17, 2020·Natural Product Reports·Zoe E Wilson, Margaret A Brimble
May 13, 2014·Natural Product Reports·Timothy R Welch, Robert M Williams
Jun 6, 2018·Marine Drugs·Xuan ZhangChang-Qi Zhao
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
May 15, 2020·Extremophiles : Life Under Extreme Conditions·Thamar Holanda da SilvaLuiz Henrique Rosa
Aug 6, 2013·Chemical Science·Nicolas BoyerMohammad Movassaghi
Mar 1, 2017·Marine Drugs·Yuan TianFeng-Chun Zhao
Sep 10, 2020·International Journal of Environmental Research and Public Health·Laura ZucconiSolveig Tosi
May 24, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariano Walter PertinoGuillermo Schmeda-Hirschmann
Jun 9, 2018·Nature Communications·Daniel HeineBarrie Wilkinson
Apr 26, 2019·Biotechnology Letters·Pengchao ZhaoShuxiao Feng
Jan 14, 2021·Journal of Natural Products·Tao ZhouYasuhiro Igarashi
Jun 6, 2015·Journal of Natural Products·Haibo ZhouTianjiao Zhu
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Sep 7, 2013·The Journal of Organic Chemistry·Salman Y Jabri, Larry E Overman
Mar 3, 2020·Journal of Natural Products·Meng-Hua WangZhong-Mei Zou

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