Cytotoxic, mutagenic and genotoxic evaluation of crude extracts and fractions from Piper jericoense with trypanocidal action

Acta Tropica
A L HamedtOmar Triana-Chávez

Abstract

The current Chagas disease treatment is based on two drugs, nifurtimox and benznidazole, which is considered unsatisfactory, not only because of the narrow therapeutic range but also because of the associated toxicity. Natural products are considered an important source of biologically active compounds against various infectious organisms. Numerous Piper species are used in traditional medicine to treat parasitic diseases. In this paper, we study the activity of extracts and fractions obtained from Piper jericoense plant against epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi. In addition, we evaluated the cytotoxic, mutagenic and genotoxic activities of the F4 fraction obtained from one of the more promising extracts. We obtained four extracts, one of which presented low toxicity and high trypanocidal activity. This extract was separated into eight fractions, and the F4 fraction presented better results than the other extracts and had a higher selectivity index than the reference drug, benznidazole. This fraction was not cytotoxic, mutagenic or genotoxic.

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Citations

Jul 16, 2016·Photochemistry and Photobiology·Juan C Mejía-GiraldoMiguel A Puertas-Mejía
Feb 9, 2017·Memórias do Instituto Oswaldo Cruz·Luz Helena VillamizarMaurilio José Soares
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Feb 27, 2018·ACS Combinatorial Science·I Ayelen RamalloRicardo L E Furlan
Aug 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paola García-Huertas, Nora Cardona-Castro
Feb 18, 2021·Current Pharmaceutical Design·Aline A Zuma, Wanderley de Souza

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