Cytotoxic, nuclear, and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cells

Cancer Letters
A J Ward, E K Matthews

Abstract

The light-activated drugs AlPcS4 and T4MPyP were studied in a pancreatic carcinoma cell line for their effects on DNA integrity, cell division, proliferation, and survival. The micronucleus assay measured nuclear changes and also the number of actively dividing cells while, under similar conditions, the MTT assay measured cell survival. When tumour cells were exposed to light, pre-treatment with AlPcS4 induced more micronuclei than did T4MPyP at the same levels of cell division and survival. Both drugs showed a correlation between phototoxicity and changes to DNA integrity so establishing micronuclei formation as an important indicator of photodynamic drug action on tumour cells.

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Citations

Sep 3, 2013·Photodiagnosis and Photodynamic Therapy·Luo-Wei WangBolin Liu Md
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Mar 1, 1997·Photochemistry and Photobiology·K Berg, J Moan
Aug 28, 2013·Bioconjugate Chemistry·Elena RanyukBrigitte Guérin
Dec 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nawal SekkatNorbert Lange
Mar 12, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Angeles VillanuevaPilar Acedo

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