PMID: 9190085Jun 1, 1997Paper

Cytotoxic prenylated flavanones from Monotes engleri

Phytochemistry
E K SeoA D Kinghorn

Abstract

From the leaves of Monotes engleri, five prenylated flavanones were isolated as constituents that displayed cytotoxic activity against several human cancer cell lines. There of these substances are novel, namely, 6-(1,1-dimethylallyl)naringenin, 6-(1,1-dimethylallyl)eriodictyol and 3'-O-methyl-6-(1,1-dimethylallyl)-eriodictyol, with the other two active substances being the known flavanones, 6,8-diprenyleriodictyol and hiravanone. Additionally, two novel, but non-cytotoxic, biogenetically related flavanones were isolated, 6-[(2RS)-hydroxy-3-methyl-3-butenyl]-8-prenyleriodictyol and 5,4'-dihydroxy-4",4"-dimethyl-5"-methyl-5"H-dihydrofurano[2",3": 6,7]flavanone. The structures of the new compounds were determined by spectral analysis 1D- and 2D-NMR experiments.

References

Jul 1, 1994·Phytochemistry·S TaharaJ Mizutani
Jan 1, 1993·Journal of Natural Products·K LikhitwitayawuidN Ruangrungsi

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Citations

Nov 6, 2003·Phytochemistry·Yu-Ling HuangChien-Chih Chen
Dec 29, 2000·Phytochemistry·J B Harborne, C A Williams
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N G Coldham, M J Sauer
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Aug 30, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W G KoB H Lee
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Oct 12, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Annekathrin Martina KeilerOliver Zierau
Jul 17, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Georg KretzschmarOliver Zierau
Dec 21, 2004·Biochemical and Biophysical Research Communications·Oliver ZierauStefan Scholz
May 4, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Dena A M AmerGünter Vollmer
Jan 13, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cheng JiangHao Yin
Sep 30, 1999·Environmental Health Perspectives·S Dev
May 7, 2016·Chemical & Pharmaceutical Bulletin·Li-Hua SuRong-Tao Li
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang LiuQingying Zhang
Jul 9, 2009·Journal of Natural Products·Yaun-Chao HuangChih-Chuang Liaw
Sep 9, 2008·Molecular and Cellular Endocrinology·Oliver ZierauGünter Vollmer

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