Abstract
Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O-beta-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of "akond mul" (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 micrograms/ml.
Citations
Jun 6, 2007·Journal of Natural Products·Shugeng CaoDavid G I Kingston
Nov 24, 2011·Biotechnology Letters·Jian SunBing Zhao
Dec 19, 2008·Pakistan Journal of Biological Sciences : PJBS·M Rowshanul HabibM Rezaul Karim
Mar 3, 2012·Parasitology Research·Kalimuthu KovendanSavariar Vincent
Jul 16, 2013·Steroids·Hanyun YouLihong Hu
Sep 10, 2013·Journal of Ethnopharmacology·Madhuri KadiyalaKannan Elango
Oct 22, 2011·Asian Pacific Journal of Tropical Medicine·M Rowshahul Habib, M Rezaul Karim
Apr 1, 2014·Natural Product Research·S R M IbrahimD T A Youssef
Apr 17, 2014·Natural Product Research·Pham Van KhangLei Ma
Oct 30, 2016·Journal of Ethnopharmacology·Supawadee ParhiraZhi-Hong Jiang
Aug 18, 2005·Phytotherapy Research : PTR·H R ChitmeSadhna Kaushik
Aug 21, 2013·Pharmacological Reports : PR·Muhammad R Habib, Muhammad R Karim
Dec 5, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhu-Nian WangHao-Fu Dai
May 16, 2003·Phytotherapy Research : PTR·Young-Jae YouByung-Zun Ahn
Jun 30, 2019·Cancers·In-Sung SongSung-Wuk Jang
Mar 1, 2009·Mycobiology·M Rowshanul Habib, M Rezaul Karim
Oct 2, 2014·Organic & Biomolecular Chemistry·Rong-Rong ZhangRen-Wang Jiang