Cytotoxic Response Profiles of Cultured Renal Epithelial and Mesenchymal Cells toSelected Aromatic Hydrocarbons

Toxicology in Vitro : an International Journal Published in Association with BIBRA
A R ParrishK S Ramos

Abstract

The cytotoxic responses of cultured rat renal cortico-tubular epithelial cells (TECs) and glomerular mesangial cells (GMCs) to selected polycyclic and polyhalogenated aromatic hydrocarbons (AHs) were evaluated to further define class specific differences in toxicity potential among these chemicals. Primary cultures of renal cells were exposed to benzo[a]pyrene (BaP, 0.3-30mum); naphthalene (NAPH, 1-1000mum); 2-methylnaphthalene (2-MNAPH, 1-1000mum), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 0.01-1nm); 2,3,7,8-tetrachlorodibenzofuran (TCDF, 0.05-5nm; and pentachlorophenol (PCP, 0.1-10mum for 4 or 24hr. Measurements of mitochondrial membrane fragility in TECs revealed that the polycyclic aromatic hydrocarbons (PAHs) (BaP, NAPH and 2-MNAPH) preferentially injured these cells relative to halogenated aromatic hydrocarbons (HAHs). Extended exposures to all AHs tested were associated with moderate mitochondrial injury in TECs. Challenge of TECs with AHs for 4hr did not modulate GSH levels, although modest increases in this tripeptide occurred on extended exposures. Similar response profiles were observed in GMCs, where PAHs elicited mitochondrial damage by 4hr, while extended challenge was associated with injury in response to all AH...Continue Reading

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Dec 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R C Bowes, K S Ramos

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Citations

Sep 2, 2000·Journal of Biochemical and Molecular Toxicology·K SchirmerN C Bols
May 31, 2011·Environmental Pollution·Brian P LankaduraiMyrna J Simpson
May 10, 2015·Toxicology Letters·Joanna Gdula-ArgasińskaPaweł Wołkow
Dec 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ho Jae HanJang Hern Lee
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Adrian NanezKenneth S Ramos
Sep 7, 2019·Journal of Translational Medicine·Hui ZhaoYing-Yong Zhao

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