Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum

Journal of Natural Products
Jun HuoJian-Min Yue

Abstract

Ten new guaiane type sesquiterpene lactones, namely, eupalinilides A-J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic acid (17), 8beta-(4'-hydroxytigloyloxy)-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4Z,11(13)-trien-6,12-olide (18), and 8beta-tigloyloxy-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4E,11(13)-trien-6,12-olide (19), were isolated from the whole plant of Eupatorium lindleyanum. Eupalinilides B (2), C (3), E (5), F (6), and I (9) have been tested for cytotoxicity against P-388 and A-549 tumor cell lines. The results showed that eupalinilides B (2) and E (5) demonstrated potent cytotoxicity. The structures of these compounds were determined by spectroscopic methods including 1D and 2D NMR spectra.

References

Jan 24, 1975·The Journal of Organic Chemistry·N FinchI H Hsu
Mar 26, 2003·Cancer Chemotherapy and Pharmacology·Bea PauwelsJan B Vermorken

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Citations

May 16, 2012·Journal of Asian Natural Products Research·Shuang-Qing WuChun-Jun Chu
Apr 21, 2016·Journal of the American Chemical Society·Trevor C JohnsonDionicio Siegel
Apr 26, 2017·The Journal of Organic Chemistry·Trevor C JohnsonDionicio Siegel
Sep 4, 2012·Acta Pharmacologica Sinica·Sheng-Ping Yang, Jian-Min Yue
Jan 22, 2008·Chemistry & Biodiversity·Man-Li ZhangQing-Wen Shi
Jul 28, 2005·Natural Product Reports·Braulio M Fraga
Oct 16, 2015·Chemistry & Biodiversity·Pei-Yu LiuMan-Li Zhang
Mar 9, 2021·Angewandte Chemie·Yang'en You, Shaozhong Ge
Feb 28, 2013·ACS Chemical Biology·Lorenzo de LichterveldePeter G Schultz
Apr 30, 2017·Journal of the American Chemical Society·Songjie YuShaozhong Ge
Aug 5, 2017·Chemical Reviews·Trevor C Johnson, Dionicio Siegel

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