Cytotoxic steroids from the Vietnamese gorgonian Verrucella corona

Steroids
Nguyen Hoai NamChau Van Minh

Abstract

Using various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A-F (1-6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8,22-dien-7-one (14), and 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8(14),22-dien-7-one (15) showed significant cytotoxicity (IC50 values ranging from 12.32 ± 1.47 to 33.77 ± 1.28 μM) against eight human cancer cell lines as LNCaP (prostate cancer), HepG2 (hepatoma cancer), KB (epidermoid carcinoma), MCF-7 (breast cancer), SK-Mel2 (melanoma), HL-60 (acute leukemia), LU-1 (lung cancer), and SW480 (colon adenocarcinoma).

Citations

Jul 20, 2019·Natural Product Research·Ninh Thi NgocChau Van Minh
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jan 24, 2019·Natural Product Research·Ngoc Ninh ThiMinh Chau Van
Dec 6, 2020·Marine Drugs·Ekaterina V ErmolenkoValery M Dembitsky
May 26, 2021·Natural Product Research·Tram Le HuyenThu Huong Tran
Sep 4, 2020·Magnetic Resonance in Chemistry : MRC·Nguyen Van ThanhChau Van Minh
Oct 19, 2020·Fitoterapia·Jiaqi XiaoQiang Diao

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