PMID: 16637294Apr 28, 2006Paper

Cytotoxic steroids with antiestrogenic activity of the 11alpha-acyloxyestra-1,3,5(10)-triene series

Bioorganicheskaia khimiia
L E GolubovskaiaV M Rzheznikov


Esterification of 3-hydroxyl group in 11-acyloxyestra-1,3,5(10)-trienes with p-[bis(2-chloroethyl)amino]phenylacetic acid led to antitumor steroids displaying antiestrogenic and cytotoxic activities. Our substances exhibit their activities on the model of murine mammary adenocarcinoma Ca-755, with inhibition of the tumor growth being 94-99%. A new approach was used for the 11alpha-hydroxylation of estra-1,3,5(10)-trienes.


Jul 1, 1989·Steroids·J BowlerA E Wakeling
Jan 1, 1983·Annals of the New York Academy of Sciences·Y SuzukiH Hirai
Mar 28, 1997·Journal of Medicinal Chemistry·J GilbertM Pons

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