PMID: 6169350Aug 1, 1981Paper

Cytotoxic T cell interactions with antigen. Potential relevance for drug-related lupus

Arthritis and Rheumatism
S Shaw, G M Shearer

Abstract

Understanding of cytotoxic T cell recognition may be relevant to the study of drug-related lupus because either cell-mediated cytotoxicity (CMC) contributes to triggering the disease or CMC provides an informative model to study T cell recognition of foreign antigen. As a model, CMC demonstrates the following: 1) Antigen presentation can occur by membrane insertion of the antigen, covalent modification of the cell surface, or cell surface adsorption of the antigen; these may be modes of presentation by which drug-related antigens induce adverse responses. 2) HLA antigens regulate a wide variety of immune responses; this may be crucial in drug-related lupus since HLA antigens may regulate autoimmune responses, may affect an individual's susceptibility to lupus, and may increase the risk for other specific adverse drug reactions.

References

Sep 29, 1977·The New England Journal of Medicine·R P de VriesJ J van Rood
Feb 1, 1978·The Journal of Experimental Medicine·A M Schmitt-VerhulstG M Shearer
Jan 1, 1977·Advances in Immunology·G M Shearer, A M Schmitt-Verhulst
Oct 27, 1979·Lancet·D D GladmanM R Liebling
Sep 7, 1978·The New England Journal of Medicine·J L ReinertsenD L Mann
Mar 1, 1979·The Journal of Experimental Medicine·S Shaw, W E Biddison
May 1, 1975·The Journal of Experimental Medicine·L J GreenbergE J Yunis
Jun 21, 1958·Nature·J J VAN ROODA VAN LEEUWEN

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.