Cytotoxic T cell recognition of Epstein-Barr virus-infected B cells. I. Specificity and HLA restriction of effector cells reactivated in vitro

European Journal of Immunology
D J MossM A Epstein

Abstract

The experiments show that the phenomenon of regression, seen exclusively in Epstein-Barr (EB) virus-infected cultures of mononuclear cells from EB virus antibody-positive donors, is mediated by cytotoxic T cells reactivated in vitro and specifically recognizing an EB virus-induced lymphocyte-detected membrane antigen LYDMA. Thus, effector T cells from regressing cultures kill autologous EB virus-transformed cells but not autologous pokeweed mitogen-stimulates lymphoblasts nor any of a range of EB virus genome-negative human hemopoietic cell lines (K562, HSB2, BJAB, EB4) particularly sensitive to nonspecific natural killer-like activities. Moreover, these reactivated effector cells exhibit classical HLA restriction of target cell recognition; in a survey of 14 effector cell donors, preferential lysis of the autologous virus-transformed line was a consistent feature, while the relative degree of lysis of allogeneic lines was in general directly related to the number of HLA-A and B antigens shared between effector and target cells. The pattern of reactivity shown by effector T cell preparations from any one donor was strikingly reproducible, and the results from a number of donors revealed differences between particular HLA-A and ...Continue Reading

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Citations

Jun 1, 1996·Reviews in Medical Virology·T J Haque, D H Crawford
Jan 1, 1982·Rheumatology International·J S GastonM A Epstein
Jan 1, 1984·Immunogenetics·E GomardJ P Lévy
Dec 31, 1998·Springer Seminars in Immunopathology·T Haque, D H Crawford
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Apr 3, 1982·Lancet
Apr 3, 1982·Lancet
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Feb 15, 1984·International Journal of Cancer. Journal International Du Cancer·I S MiskoR G Kane
Mar 15, 1985·International Journal of Cancer. Journal International Du Cancer·M T BejaranoG Klein

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