PMID: 98140Apr 1, 1978

Cytotoxic T cell responses to a syngeneic tumour: conditions for primary activation in vitro

The Australian Journal of Experimental Biology and Medical Science
H S WarrenK J Lafferty


Primary cytotoxic responses of DBA/2 lymph node cells to a syngeneic tumour (the mastocytoma P815) have been generated in vitro. The development of these responses is dependent on the addition of a soluble factor (CSCS) which is produced by concanavalin A-activated spleen cells. The response is mediated by T lymphocytes, can be detected at low effector to target cell ratios and is directed against P815 tumour-associated antigens.


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Apr 1, 1985·Australian and New Zealand Journal of Medicine·D S Nelson, C L Geczy
Jan 1, 1979·Scandinavian Journal of Immunology·H S Warren, K J Lafferty
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy

Related Concepts

Concanavalin A
Immunologic Tumoricidal Activities
Lymph Nodes
Mice, Inbred DBA
Sarcoma, Jensen
Mast-Cell Sarcoma

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