Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities.

Infection and Immunity
C J PfauD C Pevear

Abstract

The ability of two lymphocytic choriomeningitis virus substrains to induce cytotoxic T-lymphocyte (CTL) responses in intracerebrally infected mice was examined. One strain, designated A (aggressive), provoked a convulsive type of death in 100% of the mice within 8 to 9 days, whereas the other strain, designated D (docile), killed less than 10% of the mice during 28-day observation periods. CTL activity was assessed by the capacity of partially purified splenocytes to lyse 51Cr-labeled L-cell targets infected with either type of lymphocytic choriomeningitis substrain. The CTL population was identified by its sensitivity to anti-Thy-1 serum and its inability to lyse uninfected target cells or infected target cells with which it differed at the level of antigens controlled by the major histocompatibility gene complex. A strong CTL response developed in mice infected with either lymphocytic choriomeningitis substrain, although the activity provoked by substrain D was somewhat less than that seen after substrain A infection. Peak CTL activities induced by both strains occurred at about the same time. Even though docile virus replicated more extensively in the brain than did aggressive virus and fluorescent antibody staining revealed...Continue Reading

References

Jun 1, 1978·Infection and Immunity·T Morishima, K Hayashi
Feb 1, 1978·The Journal of General Virology·F J Dutko, C J Pfau
Nov 1, 1973·The Journal of Experimental Medicine·R M Zinkernagel, P C Doherty
Jan 1, 1972·Monographs in Human Genetics·J Hotchin
Jun 1, 1973·The Journal of Experimental Medicine·O Marker, M Volkert
Jun 1, 1971·The Journal of Infectious Diseases·S Suzuki, J Hotchin
Jan 1, 1980·Advances in Immunology·M J BuchmeierM B Oldstone
Dec 1, 1981·The Journal of General Virology·S JacobsonC J Pfau
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·M VOLKERTC PFAU
Mar 22, 1935·Science·E Traub

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Citations

Jun 1, 1993·Immunological Reviews·R M ZinkernagelH Hengartner
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andreas BergthalerDaniel D Pinschewer
Aug 1, 1996·Immunological Reviews·P AicheleR M Zinkernagel
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C J PfauJ K Valenti
Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brian C WareMichael B A Oldstone

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