PMID: 9557782Apr 29, 1998Paper

Cytotoxic T cells in basal cell carcinomas of skin

The American Journal of Dermatopathology
J S DengE Abell

Abstract

Previous studies have suggested the importance of CD8+ cytotoxic T-cells of hosts against neoplasms. Earlier studies and our previous investigation showed that a majority of tumor infiltrating T-cells in human basal cell carcinomas (BCCs) belonged to CD4+ T-cells. CD8+ cells were also present in the peritumor areas of human BCCs, but in smaller numbers. Published evidence indicates the importance of cytotoxic T-cells in antitumor immunity. Cytotoxic T-cells have been identified by using monoclonal antibodies against various cytotoxic T-cell components. In this study, we used monoclonal antibodies to perforin to evaluate the role of cytotoxic T-cells in the host response against basal cell carcinomas. Perforin-expressing T-cells could be identified in the infiltrate of BCCs in frozen tissue sections, and also in antigen-retrieved paraffin-embedded sections of BCCs, and the presence of perforin-expressing T-cells correlated with the infiltration of CD8+ T-cells. These results suggest that cytotoxic T-cells play a role in host defense against human BCCs.

References

Jan 2, 1988·British Medical Journal·G G GilesP Foley
Aug 29, 1986·Cell·J D Young, Z A Cohn
Aug 1, 1986·The Journal of Dermatologic Surgery and Oncology·R K RoenigkR G Wheeland
Oct 1, 1985·The British Journal of Dermatology·D R SynkowskiJ C Orlando
Nov 1, 1982·The Journal of Dermatologic Surgery and Oncology·N F EaglsteinJ E Allen
Jul 1, 1984·The Journal of Experimental Medicine·P A HenkartM P Henkart
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·G E PeoplesT J Eberlein
Jan 1, 1996·The Journal of Experimental Medicine·C M CelluzziL D Falo
Apr 1, 1996·Journal of Cutaneous Pathology·J S DengM D Tharp
Oct 1, 1996·Nature Medicine·C CondonL D Falo
Feb 1, 1985·Immunology Today·R A Robins, R W Baldwin

❮ Previous
Next ❯

Citations

Mar 20, 2002·Cancer·Mirjana Urosevic, Reinhard Dummer
Sep 2, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Zornitsa I ZlatarovaElisabeth M Messmer
Mar 4, 2000·The American Journal of Dermatopathology·P J Lespi, S D Gregorini
Jul 28, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S V SuchkovM A Paltsev
Feb 8, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gerson A Soto-PeñaLibia Vega

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.