PMID: 6170717Nov 1, 1981Paper

Cytotoxic T cells specific for antigens expressed on surface immunoglobulin-positive cells

The Journal of Experimental Medicine
J FormanE S Vitetta

Abstract

C.B-20 mice were immunized with splenocytes or B leukemia cells (BCL1) from Ig H chain allotype congenic strains. Spleen cells from these immunized mice were rechallenged in vitro to generate H-2-restricted cytotoxic T cells that were specific for target antigens controlled by genes linked to the Ig H chain locus. The anti-Ig H cytotoxic T cells detected an antigen(s) expressed only on surface Ig+ cells. Thus, T cell lymphoblasts, eight BALB/c myeloma cell lines, and a T cell lymphoma were not lysed by the effector cells. In contrast, B cell lymphoblasts and the surface Ig+ BCL1 cells were sensitive to lysis. A surface Ig- hybridoma (which secretes the IgM from the BCL1 cells) generated by fusing BCL1 cells to X63 myeloma cells was not killed by the effector cells. These data indicate that cytotoxic T cells specific for antigenic determinants on either surface IgM+ or IgD+ or on a molecule that is coordinately expressed on IgM+ or IgD+ cells can be generated and that such cells might play a role in regulating the growth of normal B cells or surface Ig+ tumor cells in vivo.

References

Jan 1, 1977·Immunological Reviews·E Simpson, R D Gordon
Feb 1, 1978·The Journal of Experimental Medicine·A M Schmitt-VerhulstG M Shearer
Mar 1, 1977·The Journal of Experimental Medicine·M J Bosma, G C Bosma
Apr 13, 1978·Nature·S Slavin, S Strober
Oct 1, 1979·The Journal of Experimental Medicine·J Forman, J W Streilein
Jan 1, 1975·Transplantation Reviews·L A HerzenbergC M Metzler
Jan 1, 1972·Transplantation Reviews·J AnderssonG Möller
Aug 1, 1981·The Journal of Experimental Medicine·H R SnodgrassD B Wilson

❮ Previous
Next ❯

Citations

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V M SandersE S Vitetta
Jan 1, 1982·Immunological Reviews·Y J Rosenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.