Cytotoxic T-lymphocyte-associated protein 4 gene polymorphism is related to rheumatoid arthritis in Egyptian population

Archives of Physiology and Biochemistry
Shaimaa A FattahDina M Abo-Elmatty

Abstract

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a CD28-family receptor expressed on T-cells which suppresses T cell proliferation. CTLA-4 -318C/T polymorphism is involved in regulation of CTLA-4 expression. The study aimed to investigate the genetic association of CTLA-4 -318C/T polymorphism with rheumatoid arthritis (RA) and the activity and severity of the disease in the Egyptian population. A single nucleotide polymorphism (rs5742909) in CTLA-4 was genotyped in 100 RA patients and 100 healthy controls using polymerase chain reaction-restriction fragment length polymorphism. Diagnostic tests were measured for RA patients. The frequency of T allele in RA patients was significantly higher than in the control subjects (p = 0.002). CT and TT genotypes had high C-reactive protein, erythrocyte sedimentation rate and disease activity score 28 while CC genotype had a high rheumatoid factor. A minor allele of CTLA-4 rs5742909 polymorphism was associated with RA and the activity but not the severity of the disease.

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Citations

Jul 12, 2018·Journal of Clinical Laboratory Analysis·Erika Fabiola López-VillalobosEdith Oregon-Romero
Sep 19, 2020·PloS One·Muhammad Muaaz AslamM Ilyas Kamboh
Apr 4, 2021·International Journal of Molecular Sciences·Jakub RosikAndrzej Pawlik
Jul 6, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mohammad Javad MousaviNima Rezaei

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