PMID: 7520476Sep 1, 1994Paper

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope

The Journal of Experimental Medicine
A BertolettiC Ferrari

Abstract

Mutations that abrogate recognition of a viral epitope by class I-restricted cytotoxic T lymphocyte (CTL) can lead to viral escape if the CTL response against that epitope is crucial for viral clearance. The likelihood of this type of event is low when the CTL response is simultaneously directed against multiple viral epitopes, as has been recently reported for patients with acute self-limited hepatitis B virus (HBV) infection. The CTL response to HBV is usually quite weak, however, during chronic HBV infection, and it is generally acknowledged that this is a major determinant of viral persistence in this disease. If such individuals were to produce a mono- or oligospecific CTL response, however, negative selection of the corresponding mutant viruses might occur. We have recently studied two HLA-A2-positive patients with chronic hepatitis B who, atypically, developed a strong HLA-A2-restricted CTL response against an epitope (FLPSDFFPSV) that contains an HLA-A2-binding motif located between residues 18-27 of the viral nucleocapsid protein, hepatitis B core antigen (HBcAg). These patients failed, however, to respond to any of other HLA-A2-restricted HBV-derived peptides that are generally immunogenic in acutely infected patients...Continue Reading

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Citations

Aug 1, 1995·Journal of Medical Virology·H NiitsumaT Toyota
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Sep 17, 2009·Journal of Clinical Immunology·Jian GeYu-Chen Fan
Mar 3, 2011·Immunologic Research·Lindsay J Edwards, Brian D Evavold
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Aug 1, 1995·Current Opinion in Immunology·A FrancoF V Chisari
Sep 29, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Heng-Gui LiuFu-Sheng Wang
Jun 25, 2003·Journal of Hepatology·Antonio Bertoletti, Nikolai V Naoumov
Jan 8, 2004·Journal of Hepatology·Carlo FerrariSimona Urbani
Jan 6, 2000·Journal of Hepatology·C FerrariF Fiaccadori
Feb 27, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christine I WooddellDavid L Lewis
Nov 30, 2006·Immunology and Cell Biology·J Judy Chang, Sharon R Lewin
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P Curry, M Koziel
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A WeinerC M Walker
Apr 19, 2000·The Journal of Experimental Medicine·B Rehermann
May 8, 2002·The Journal of Experimental Medicine·Stephanie ReignatAntonio Bertoletti
Jun 9, 2005·The Journal of Experimental Medicine·Ian TesterHugo R Rosen
Sep 29, 2011·The Cancer Journal·Christopher S Hourigan, Hyam I Levitsky
Jan 1, 1997·Journal of Viral Hepatitis·P Borrow
Jul 22, 2005·Immunology and Cell Biology·Yanfei XuAlessandra Franco
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Anthony Tanoto TanAntonio Bertoletti
Mar 18, 2011·Journal of Clinical Microbiology·Xin ZhengChengyao Li
Jun 26, 2009·Journal of Virology·Angela WahlWilliam H Hildebrand
Sep 19, 2008·Journal of Virology·Anthony Tanoto TanAntonio Bertoletti

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