Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection

The Journal of Clinical Investigation
B RehermannF V Chisari

Abstract

Clearance of the hepatitis B virus (HBV) during acute hepatitis is associated with a strong, polyclonal, multispecific cytotoxic T lymphocyte (CTL) response to the viral envelope, nucleocapsid and polymerase proteins that persists for decades after clinical recovery. In contrast, chronically infected patients usually fail to mount a strong CTL response to this virus. In this study we demonstrate that chronically infected patients who experience a spontaneous or interferon-induced remission develop a CTL response to HBV that is similar in strength and specificity to patients who have recovered from acute hepatitis. The results suggest that specific immunotherapeutic enhancement of the CTL response to HBV should be possible in chronically infected patients, and that it could lead to viral clearance in these individuals with resolution of chronic liver disease.

References

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Citations

Jul 9, 1999·Reviews in Medical Virology·A R Marques, S E Straus
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YotsuyanagiK Koike
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GeisslerJ R Wands
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HeathcoteR Chestnut
Sep 5, 2002·Reviews in Medical Virology·Susanne BeckebaumGuido Gerken
Jan 1, 1997·Springer Seminars in Immunopathology·K M ChangF V Chisari
May 26, 2007·Journal of Clinical Immunology·Changqing XuBangwei Cao
Oct 24, 2001·Antiviral Research·S Zeuzem, V Carreño
Mar 23, 2000·Journal of Hepatology·A S Lok
Aug 1, 1996·Current Opinion in Immunology·L G Guidotti, F V Chisari
Dec 17, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Christian DrostenStephan Günther
Oct 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-M ChuY-F Liaw
Oct 30, 1999·Clinical and Experimental Immunology·P D HodgsonT I Michalak
Jun 24, 2000·Journal of Viral Hepatitis·S Locarnini
Sep 6, 2000·Journal of Viral Hepatitis·M K Maini, A Bertoletti
Dec 2, 2000·Journal of Gastroenterology and Hepatology·S Locarnini
Mar 16, 2002·Journal of Gastroenterology and Hepatology·Hakan SenturkSelim Badur
Apr 19, 2000·The Journal of Experimental Medicine·B Rehermann
May 8, 2002·The Journal of Experimental Medicine·Stephanie ReignatAntonio Bertoletti
Aug 31, 2006·Journal of Clinical Gastroenterology·Nayar ManuChandy Rajiv
Jul 25, 2009·Journal of Virology·Shinichi AsabeFrancis V Chisari

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