Cytotoxic trichothecene macrolides from the endophyte fungus Myrothecium roridum

Journal of Asian Natural Products Research
Hong-Xin LiuWeimin Zhang

Abstract

A new cytotoxic roridin-type trichothecene macrolide named epiroridin acid (1) and two known compounds epiroridin E (2) and mytoxin B (3) were isolated from the liquid culture of Myrothecium roridum A553, which was isolated from the medicinal plant Pogostemon cablin. The structure of the new macrolide (1) was elucidated by extensive spectroscopic measurements (UV, IR, MS, and 1D and 2D NMR) analyses. All isolated compounds (1-3) were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound (1) exhibited well cytotoxicity against the four selected tumor cell lines.

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Nov 14, 1997·The Journal of Antibiotics·T SugawaraG Okada
Oct 9, 1999·Journal of Natural Products·B B Jarvis, S Wang
Mar 22, 2000·Journal of Agricultural and Food Chemistry·M MiyazawaH Kosaka
May 25, 2002·Journal of Natural Products·Khisal A AlviIrwin A Braude

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Citations

Oct 25, 2017·Journal of Asian Natural Products Research·Hong-Xin LiuWei-Min Zhang
Jan 3, 2019·Natural Product Research·Hong-Xin LiuWei-Min Zhang
Feb 14, 2019·Organic & Biomolecular Chemistry·Hong-Xin LiuWei-Min Zhang
May 24, 2019·Journal of Asian Natural Products Research·Tian-Xiao LiChun-Ping Xu
Apr 5, 2018·Frontiers in Chemistry·Haishan LiuWeiming Zhu
Sep 24, 2021·Microbial Ecology·Loan Edel Villalobos-FloresJaime García-Mena
Oct 12, 2021·International Journal of Biological Macromolecules·Wei YeWeimin Zhang

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Methods Mentioned

BETA
NMR
column chromatography

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