Cytotoxic triterpene diglycosides from the sea cucumber Stichopus horrens

Bioorganic & Medicinal Chemistry Letters
Nguyen Xuan CuongChau Van Minh

Abstract

Using various chromatographic separation techniques, eight triterpene diglycosides (1-8), including four new compounds namely stichorrenosides A-D (1-4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR. Their in vitro cytotoxic activity against five human cancer cell lines, Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma), was evaluated using SRB methods. Stichorrenoside D (4), stichoposide A (5), and 3β-O-[β-d-xylopyranosyl-(1→2)-β-d-xylopyranosyl]-23S-acetoxyholost-7-ene (7) showed strong cytotoxicity on all five tested cancer cell lines, whereas significant effect was observed for stichorrenoside C (3) and stichoposide B (6).

Citations

Oct 19, 2017·Marine Drugs·Muhammad Abdul Mojid MondolMohamad Tofazzal Islam
Sep 19, 2017·Investigational New Drugs·Teresa Liliana Wargasetia, Widodo
Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Sep 25, 2017·Natural Product Research·Le Thi VienChau Van Minh
Jun 16, 2019·Marine Drugs·Emily J S ClaereboudtIgor Eeckhaut
May 5, 2018·International Journal of Molecular Sciences·Yuri Khotimchenko
Jun 23, 2018·Journal of Agricultural and Food Chemistry·Ying-Cai ZhaoYu-Ming Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Nguyen Xuan CuongChau Van Minh
Chemical & Pharmaceutical Bulletin
Nguyen Hoai NamChau Van Minh
Bioorganic & Medicinal Chemistry Letters
Nguyen Thi HuongChau Van Minh
© 2022 Meta ULC. All rights reserved